| IED ID | IndEnz0002010298 |
| Enzyme Type ID | protease010298 |
| Protein Name |
Zinc metalloproteinase alsophinase EC 3.4.24.- Snake venom metalloproteinase SVMP Fragment |
| Gene Name | |
| Organism | Borikenophis portoricensis (Puerto Rican racer) (Alsophis portoricensis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Dipsadidae Borikenophis Borikenophis portoricensis (Puerto Rican racer) (Alsophis portoricensis) |
| Enzyme Sequence | QDTYLNAKKYIEFYLVVDNGMFXKYSXXFTV |
| Enzyme Length | 31 |
| Uniprot Accession Number | P0DJH4 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by 1,10-phenanthroline. {ECO:0000269|PubMed:22349739}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom zinc metalloprotease that has potent hemorrhagic activity, fibrinogenolytic activity on the alpha-subunit of human fibrinogen (FGA) in vitro and provokes necrosis in skin, muscle and lung tissues. May contribute to local edema and ecchymosis induced by venom. Hydrolyzes model substrate (beta-chain of insulin) at Ala(14)-Leu(15). {ECO:0000269|PubMed:22349739}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (1); Modified residue (1); Non-terminal residue (1) |
| Keywords | Calcium;Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Hemorrhagic toxin;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Myotoxin;Protease;Pyrrolidone carboxylic acid;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:22349739 |
| Post Translational Modification | PTM: Contains 9 disulfide bonds. {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 3,732 |
| Kinetics | |
| Metal Binding | METAL 12; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |