| IED ID | IndEnz0002010303 |
| Enzyme Type ID | protease010303 |
| Protein Name |
Warthog protein 1 Cleaved into: Warthog protein 1 N-product; Warthog protein 1 C-product |
| Gene Name | wrt-1 ZK1290.12 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MMVMNPLTATFLAALIGTAASASCGSSGIPFRFEVLPSGQPVLGCGSPTCFGAENGGRDLRHDSSFMAGADGDDGFFRDGDLARVRVRDPDAPAQMANCPREFSSSSCSNPMTWVGGFKASDNGDLSLQCCHYEGLRFAQEVGRPVVHPGEVYSGGEVLRDGRQTGFDAISNVRKITSGDGTVAYEVTVTRMNCLPNPGEESNEVSFDIQRDIGRILDKVGETAASGVQTNHIEADQRLSPSTDVQSDSYVSPTEADPQEPVEQFVQVGEQVVPVTSAGYYYPVASGVPACFTGNSKVMTPAGEKSMADLSVGDMVMTYEYGKMTYTRVASWLHRLPDTKAAFIKLTTEQGAIIDMTPQHFIYKANCVTEEMELVYAEDMTIGDCLMVKENEKLVMTTISEKSTFYETGVYAPMTETGDLIVDDVYASCHNVVKANTLSHTFLNFATSVQQKMRSVLGSLEETGHLPATSEFFLNIIDVLLPHKY |
| Enzyme Length | 485 |
| Uniprot Accession Number | Q94128 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Intercellular signal essential for a variety of patterning events during development. {ECO:0000250|UniProtKB:Q02936}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (3); Compositional bias (1); Erroneous initiation (1); Region (1); Signal peptide (1); Site (3) |
| Keywords | Autocatalytic cleavage;Cell membrane;Developmental protein;Hydrolase;Membrane;Protease;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Warthog protein 1]: Secreted {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250}.; SUBCELLULAR LOCATION: [Warthog protein 1 N-product]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Warthog protein 1 C-product]: Secreted, extracellular space {ECO:0000250}. Note=Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: The C-terminal domain displays an autoproteolysis activity. {ECO:0000269|PubMed:8689684}. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10523520; 16204193; 20439776; 20610404; 21085631; 21177967; 22560298; 23800452; 25487147; 27506200; |
| Motif | |
| Gene Encoded By | |
| Mass | 52,513 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |