| IED ID | IndEnz0002010317 |
| Enzyme Type ID | protease010317 |
| Protein Name |
Dibasic-processing endoprotease EC 3.4.21.- |
| Gene Name | XPR6 YALI0F13189g |
| Organism | Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Dipodascaceae Yarrowia Yarrowia lipolytica (Candida lipolytica) Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
| Enzyme Sequence | MLRKFILGLLLASQAVAQLPHKERDYDSRVYVALSLRDGLDPREFEASVSGLDHGQWTFEHPVGTIPNTYVFSAPKEYAPIENIRDQDRLEVAGGVLAKRELRKREKLQKKYGMSEEDVEKRLVALERLDYDWSERGLGSLEVLSERRIHKRAPVNWTEEEMEYLKEIKRRAEEAQKAQDDKGDKKEDQKDDKKEGQEAQKEGDKEDNKGDDKEDGEEDDDDDEDEDDDDASPAMPVQWKPVDESMYGGMPDDSLYDVYRKYYPDEVGIKDPSLWKQWYLHNVHKAGHDLNVTGLWLRNVTGWGVVTAVVDDGLDMNAEDIKANYFAEGSWDFNFNKSDPKPSSHDDYHGTRCAGEIAAVRNNVCGVGVAYDSKVAGIRILSKEIAEDIEALAINYEMDKNDIYSCSWGPPDNGQTMARPGKVVKDAMVNAITNGRQGKGNVFVFASGNGGSRGDNCNFDGYTNSIYSITVGALDFNDGHPYYSEACSANMVVTYSSGSEHYIVGTDINAIDDKSAAPRCQNQHGGTSAAAPLAAGVFALALSVRPDLTWRDMQYLALYSAVEINSNDDGWQDTASGQRFHHQFGYGKLDASKIVELAEGWNLVNNQTSFHSEVKTVSQKVKYNEPLKSVITVTRDDLDKVNFKRAEHITAVLNLEASYRGHVRVLLKGPRGVVSELAALRRDDRSKDGYDNWAFMSVAHWADEGEGDWELTVENTGEQDQVELVNWQLNVFGEQKDKREENKEGESKPEDENKEGEKEGEKKPEDENKEEGNKEDDKGDQKEDKPEDKPEDKPEDTPEDKPEDKPEDAPEDKPSDEKKPEEKPEEKPVDNSDSSSDSSDSHTSWWPDLSSKKSAWLYGAVLLVGGFIAVIGIYACVTRRNRVRRNRSKDAPSASSFEFDLIPHDDSDDDFVYPEDTHRRSGDNDRLYDPFAEVEDDDDMFRISDEGEDAHDVEPELNRVSMEADKRDNDRQNLLG |
| Enzyme Length | 976 |
| Uniprot Accession Number | P42781 |
| Absorption | |
| Active Site | ACT_SITE 311; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 349; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 528; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (6); Domain (2); Glycosylation (6); Region (3); Signal peptide (1); Transmembrane (2) |
| Keywords | Calcium;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 110,024 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |