| IED ID | IndEnz0002010323 |
| Enzyme Type ID | protease010323 |
| Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
| Gene Name | DDI1 CNBC6770 |
| Organism | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Enzyme Sequence | MRLTIIAPDSVHEHEVSPSLLIQDIINIVEATADLPPAVIVLTSDAGTPLTDPTRTLESYGLNGETATIFLTPTGPPVASSSSIPFPDADADIERMRLQALGNPSLMNDLRERDPETFAAIQGGTQSFKKALQLAQSRQRDAEFEKQRQIEALNADPYDIEAQKKIEEAIRMEAVLENMQHAMEYSPESFGNVTMLYINVEVNGHPVKAFVDSGAQTTIISPECAEQCGIMRLLDTRFAGMAEGVGTARILGRIHSAQIKLGSLYLPCAFSVLEGRSVDLLFGLDMLKRHQCCIDLSTNTLRINNTEVPFLSEHELPDKARRRGEAQVAGEMGDAAGQGVKAGVASPKIGKKTFPGEGHALGAGSSTGPGTATGSASATGARTGGTASVPSPSNRWKEDDIQTLVNLGAPRAQAIQLLEASGGNVDVAASMLFG |
| Enzyme Length | 434 |
| Uniprot Accession Number | P0CS15 |
| Absorption | |
| Active Site | ACT_SITE 212; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Domain (2); Region (1) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 46,131 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |