| IED ID | IndEnz0002010344 |
| Enzyme Type ID | protease010344 |
| Protein Name |
Ficolin-3 Collagen/fibrinogen domain-containing lectin 3 p35 Collagen/fibrinogen domain-containing protein 3 Hakata antigen |
| Gene Name | FCN3 FCNH HAKA1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR |
| Enzyme Length | 299 |
| Uniprot Accession Number | O75636 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. {ECO:0000269|PubMed:11907111, ECO:0000269|PubMed:17215869}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (14); Chain (1); Compositional bias (1); Disulfide bond (3); Domain (2); Glycosylation (1); Helix (7); Metal binding (4); Modified residue (6); Region (2); Sequence conflict (2); Signal peptide (1); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Calcium;Collagen;Complement activation lectin pathway;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydroxylation;Immunity;Innate immunity;Lectin;Metal-binding;Reference proteome;Repeat;Secreted;Signal |
| Interact With | P17927; Q15485; P02751; P9WQP3; P9WQP1 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct. |
| Modified Residue | MOD_RES 50; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:9694814; MOD_RES 53; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:9694814; MOD_RES 59; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:9694814; MOD_RES 65; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:9694814; MOD_RES 68; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:9694814; MOD_RES 77; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:9694814 |
| Post Translational Modification | PTM: The N-terminus is blocked. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000269|PubMed:15340161 |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 2J5Z; 2J60; 2J64; |
| Mapped Pubmed ID | 10925294; 12367778; 12396008; 14280442; 15199963; 15804047; 17303612; 17469142; 18006063; 18032536; 18261799; 18596036; 19109177; 19208603; 19220833; 19939495; 20237496; 20375619; 21085669; 21851923; 22082351; 22226667; 22238349; 22471352; 22670778; 22851708; 23107985; 23142462; 23596511; 23744477; 25001927; 25042985; 25064124; 25069872; 25083730; 25222012; 26074063; 26133042; 26154564; 26377840; 26627059; 26795763; 26868430; 27312152; 27631981; 27856789; 27981461; 28039962; 28241035; 28432700; 29386009; 29491225; 30949171; 31373851; 32094208; 32601370; 33232720; 33499929; 33591573; 33686686; 33859174; 6019133; 70787; |
| Motif | |
| Gene Encoded By | |
| Mass | 32,903 |
| Kinetics | |
| Metal Binding | METAL 237; /note="Calcium"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J5Z, ECO:0007744|PDB:2J60"; METAL 239; /note="Calcium"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J5Z, ECO:0007744|PDB:2J60"; METAL 241; /note="Calcium; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J5Z, ECO:0007744|PDB:2J60"; METAL 243; /note="Calcium; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:17215869, ECO:0007744|PDB:2J5Z, ECO:0007744|PDB:2J60" |
| Rhea ID | |
| Cross Reference Brenda |