| IED ID | IndEnz0002010358 |
| Enzyme Type ID | protease010358 |
| Protein Name |
Leishmanolysin-like peptidase EC 3.4.24.- |
| Gene Name | Y43F4A.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKPRLIFIFFACYFLNFLPFSNQLPCSYQNPRIEDILLEVPIEHEHPHRHRRGLPSSDPTSPPVEKFAPLRIQLHYDKSIQNLTAEVQNFVNTTLLPEAVGYWENALRVRPMTTPIRLRRKCISSFYYYKQGMRNVACDKGCRERTTCGEADIPRDHLLDCLACNNTDDCKTTGELGEGVKDTDFILYVTAHDSKRCEGPETLSYAAHCQQEADFDRPIAGNVNLCPSALSVHNHDYEILTSTVKHEILHALGFSVGLYAFFRDSEGKPRTKRNRYGRPTSLNKQKGYYDWDSNTITTVLRENWWTGEGKVIHPIHMMVTPKVREEARRHFGCDKLEGAELENQGGEGTYLTHWEKRAYENEAMTGTHTQNPVYSRLTLAFLEDTGWYQPNYEVAEDLHWGKQLGCDFAMKSCGEWIHEKKILGEDAYPYCSDIKHDGSKSMAITRCTTQRDSLALCNLVPFQKELPSQYRNFMSLPGVNPDGAKYYGGSVEMADYCPFLQEFEWKLIDKTQHKDSRCELEGNGKEGEDILEVYGANSKCFEFPKPWTERKCGRIRVLSHYMAGCYEHQCTNGTLYVGSYNATDMYPCYAENQKIHIKKVVDGWLREGSLICPKCEDYCTNCGPPIVIPDYIGDPELDEPCSSNFKLSVLAFLCYLIFLHIRS |
| Enzyme Length | 663 |
| Uniprot Accession Number | O62446 |
| Absorption | |
| Active Site | ACT_SITE 247; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Essential for the coordination of mitotic progression, and also plays a role in cell migration. {ECO:0000250|UniProtKB:Q9VH19}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (3) |
| Keywords | Cell cycle;Cell division;Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Mitosis;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells (By similarity). {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 15338614; 17486083; 17850180; 21085631; 21177967; 21367940; 22267497; 22286215; 22560298; 23800452; 24884423; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 76,050 |
| Kinetics | |
| Metal Binding | METAL 246; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 250; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 353; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |