| IED ID | IndEnz0002010378 |
| Enzyme Type ID | protease010378 |
| Protein Name |
Serine protease 55 EC 3.4.21.- Testis serine protease 1 T-SP1 |
| Gene Name | PRSS55 TSP1 UNQ9391/PRO34284 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MLLFSVLLLLSLVTGTQLGPRTPLPEAGVAILGRARGAHRPQPPHPPSPVSECGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLTSPSMEIKEVASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPKLTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWIEKVTQLEGRPFNAEKRRTSVKQKPMGSPVSGVPEPGSPRSWLLLCPLSHVLFRAILY |
| Enzyme Length | 352 |
| Uniprot Accession Number | Q6UWB4 |
| Absorption | |
| Active Site | ACT_SITE 108; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 156; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 250; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction. {ECO:0000250|UniProtKB:Q14BX2}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (1); Lipidation (1); Natural variant (2); Propeptide (1); Region (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Alternative splicing;Cell membrane;Cytoplasm;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Reference proteome;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18844450}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q14BX2}. Cytoplasm, cytosol {ECO:0000269|PubMed:18844450}. Note=Mainly found in the membrane part of the cells and only in small amounts in the cytosol. {ECO:0000269|PubMed:18844450}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:18844450}. Note=Present primarily in the cytosol and only in minor amounts in the membrane fraction. {ECO:0000269|PubMed:18844450}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 38,856 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |