| IED ID | IndEnz0002010415 |
| Enzyme Type ID | protease010415 |
| Protein Name |
Presenilin-2 PS-2 Zf-PS2 EC 3.4.23.- Pre2 |
| Gene Name | psen2 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MNTSDSEEDSYNERSALVQSESPTVPSYNQDNAMSLPQDTDSKRSGAVRSRSASGSGDAGPVDRERADTPDGEEEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTEKSGQRLIYTPFEEDPNSVGQRLLNSVLNTLVMISVIVFMTIILVLLYKYRCYKFIHGWLILSSLMLLFWFSFMYLGEVFKTYNVAMDYPTLLMIIWNFGVVGMICIHWKGPLRLQQAYLIVISALMALIFIKYLPEWSAWVILGAISIYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWMVGMADSNNPDSAGERRRSGGGVRTQEGVESEHDAPQAGRRQYSAEEDLEEDRGVKLGLGDFIFYSVLVGKAAATGGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFSTDNLVRPFMDSLAAHQYYI |
| Enzyme Length | 441 |
| Uniprot Accession Number | Q90ZE4 |
| Absorption | |
| Active Site | ACT_SITE 262; /evidence=ECO:0000250; ACT_SITE 360; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Intramembrane (1); Motif (1); Region (2); Sequence conflict (2); Topological domain (10); Transmembrane (8) |
| Keywords | Endoplasmic reticulum;Golgi apparatus;Hydrolase;Membrane;Notch signaling pathway;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17981814; 19563801; 23666177; 30359395; 32658922; |
| Motif | MOTIF 407..409; /note=PAL |
| Gene Encoded By | |
| Mass | 49,169 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |