| IED ID | IndEnz0002010433 |
| Enzyme Type ID | protease010433 |
| Protein Name |
Tumor necrosis factor receptor superfamily member 10A Death receptor 4 TNF-related apoptosis-inducing ligand receptor 1 TRAIL receptor 1 TRAIL-R1 CD antigen CD261 |
| Gene Name | TNFRSF10A APO2 DR4 TRAILR1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE |
| Enzyme Length | 468 |
| Uniprot Accession Number | O00220 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:9430227}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (7); Chain (1); Disulfide bond (7); Domain (1); Glycosylation (1); Modified residue (4); Mutagenesis (6); Natural variant (8); Region (1); Repeat (3); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (1) |
| Keywords | 3D-structure;Apoptosis;Cell membrane;Cytoplasm;Disulfide bond;Glycoprotein;Membrane;Methylation;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | Q96P48; Q14790; Q08380; P50591 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22240897}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:22240897}. Cytoplasm, cytosol {ECO:0000269|PubMed:22240897}. Note=Palmitoylation is required for association with membranes. {ECO:0000269|PubMed:22240897}. |
| Modified Residue | MOD_RES 52; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 424; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 463; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:20068231"; MOD_RES 466; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231" |
| Post Translational Modification | PTM: Palmitoylated (PubMed:19090789). Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789). Palmitoylated by ZDHHC3 (Probable). {ECO:0000269|PubMed:19090789, ECO:0000305|PubMed:22240897}. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 5CIR; |
| Mapped Pubmed ID | 10777207; 10830912; 10837247; 10894160; 11382926; 11384965; 11463813; 11717445; 11844843; 11862476; 12082627; 12198154; 12239152; 12388693; 12421985; 12488957; 12620239; 12620240; 12649168; 12808117; 12839575; 12920112; 12927928; 14506242; 14534720; 14576771; 14623878; 15024054; 15289308; 15301860; 15334061; 15356269; 15452120; 15480430; 15538968; 15608691; 15655781; 15757891; 15760909; 15861184; 15863153; 15921376; 15972852; 15975957; 16012731; 16051735; 16217763; 16226105; 16230375; 16529749; 16544055; 16778114; 16847314; 17035413; 17047155; 17070520; 17075118; 17160022; 17327223; 17666396; 17881904; 17983809; 18163425; 18190721; 18203008; 18421578; 18511705; 18556450; 18590575; 18633131; 18676680; 18789900; 18981952; 19070628; 19074831; 19074885; 19148581; 19170196; 19203830; 19212626; 19278658; 19305384; 19349211; 19350268; 19379558; 19416807; 19424623; 19427028; 19434100; 19453261; 19505916; 19524512; 19573080; 19625176; 19637313; 19639179; 19643596; 19692168; 19773279; 19789190; 19913121; 20103630; 20237496; 20308068; 20354842; 20363213; 20421368; 20430723; 20453000; 20484047; 20556591; 20568250; 20628086; 20638129; 20666744; 20673328; 20677014; 20696707; 20714870; 20800603; 20802294; 20852190; 20875141; 20889918; 20951169; 21195543; 21235526; 21279373; 21367858; 21484799; 21519792; 21685476; 21700414; 21737330; 21769428; 21785270; 21785459; 21953056; 22158615; 22183068; 22246181; 22258765; 22392486; 22401174; 22447040; 22665066; 22695614; 22817896; 22824792; 22948392; 23050498; 23284732; 23300075; 23306613; 23423784; 23460812; 23584885; 23661154; 23686163; 23806100; 23815209; 23857473; 23959437; 24078627; 24085293; 24136227; 24212133; 24235014; 24379239; 24492941; 24551275; 24587306; 24695582; 24761920; 24764293; 25026275; 25293521; 25605010; 25605161; 25691252; 25770212; 25798684; 25845236; 25955868; 26138346; 26238205; 26275133; 26297860; 26315998; 26404509; 26418999; 26518902; 26561202; 26708505; 26718429; 27492861; 27721019; 27750195; 27780136; 28039489; 28108622; 28120533; 28981087; 29278689; 29446085; 29473798; 29638207; 29681455; 30064384; 30430148; 30468458; 30514120; 30589515; 30912136; 30945308; 31094932; 31114586; 31183506; 32342239; 32692906; 33269432; 33664875; 34198757; 34342264; 8777713; 9242610; 9311998; 9326928; 9880531; |
| Motif | |
| Gene Encoded By | |
| Mass | 50,089 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |