| IED ID | IndEnz0002010449 |
| Enzyme Type ID | protease010449 |
| Protein Name |
Collectin-10 Collectin liver protein 1 CL-L1 Collectin-34 CL-34 |
| Gene Name | COLEC10 CLL1 UNQ366/PRO702 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MNGFASLLRRNQFILLVLFLLQIQSLGLDIDSRPTAEVCATHTISPGPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDQGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTVCDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRETEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREGQYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHLTMYFVCEFIKKKK |
| Enzyme Length | 277 |
| Uniprot Accession Number | Q9Y6Z7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). {ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Disulfide bond (2); Domain (2); Glycosylation (1); Natural variant (2); Region (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Calcium;Collagen;Cytoplasm;Disease variant;Disulfide bond;Glycoprotein;Golgi apparatus;Lectin;Mannose-binding;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28301481}. Golgi apparatus {ECO:0000250|UniProtKB:Q8CF98}. Cytoplasm {ECO:0000269|PubMed:10224141}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10925294; 12396008; 14280442; 15199963; 20237496; 24174618; 25710878; 26154564; 26173080; 27057739; 27341702; 30108587; 32751929; 6019133; 70787; |
| Motif | |
| Gene Encoded By | |
| Mass | 30,705 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |