| IED ID | IndEnz0002010487 |
| Enzyme Type ID | protease010487 |
| Protein Name |
Nisin leader peptide-processing serine protease NisP EC 3.4.21.- |
| Gene Name | nisP |
| Organism | Lactococcus lactis subsp. lactis (Streptococcus lactis) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Streptococcaceae Lactococcus (lactic streptococci) Lactococcus lactis Lactococcus lactis subsp. lactis (Streptococcus lactis) |
| Enzyme Sequence | MKKILGFLFIVCSLGLSATVHGETTNSQQLLSNNINTELINHNSNAILSSTEGSTTDSINLGAQSPAVKSTTRTELDVTGAAKTLLQTSAVQKEMKVSLQETQVSSEFSKRDSVTNKEAVPVSKDELLEQSEVVVSTSSIQKNKILDNKKKRANFVTSSPLIKEKPSNSKDASGVIDNSASPLSYRKAKEVVSLRQPLKNQKVEAQPLLISNSSEKKASVYTNSHDFWDYQWDMKYVTNNGESYALYQPSKKISVGIIDSGIMEEHPDLSNSLGNYFKNLVPKGGFDNEEPDETGNPSDIVDKMGHGTEVAGQITANGNILGVAPGITVNIYRVFGENLSKSEWVARAIRRAADDGNKVINISAGQYLMISGSYDDGTNDYQEYLNYKSAINYATAKGSIVVAALGNDSLNIQDNQTMINFLKRFRSIKVPGKVVDAPSVFEDVIAVGGIDGYGNISDFSNIGADAIYAPAGTTANFKKYGQDKFVSQGYYLKDWLFTTANTGWYQYVYGNSFATPKVSGALALVVDKYGIKNPNQLKRFLLMNSPEVNGNRVLNIVDLLNGKNKAFSLDTDKGQDDAINHKSMENLKESRDTMKQEQDKEIQRNTNNNFSIKNDFHNISKEVISVDYNINQKMANNRNSRGAVSVRSQEILPVTGDGEDFLPALGIVCISILGILKRKTKN |
| Enzyme Length | 682 |
| Uniprot Accession Number | Q07596 |
| Absorption | |
| Active Site | ACT_SITE 259; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 306; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 512; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Cleaves the lantibiotic nisin precursor peptide. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Antibiotic biosynthesis; nisin biosynthesis. |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (19); Chain (1); Domain (1); Helix (15); Modified residue (1); Motif (1); Propeptide (2); Sequence conflict (1); Signal peptide (1); Turn (4) |
| Keywords | 3D-structure;Cell wall;Hydrolase;Peptidoglycan-anchor;Protease;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}; Peptidoglycan-anchor {ECO:0000305}. |
| Modified Residue | MOD_RES 655; /note=Pentaglycyl murein peptidoglycan amidated threonine; /evidence=ECO:0000255|PROSITE-ProRule:PRU00477 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4MZD; |
| Mapped Pubmed ID | 24914961; |
| Motif | MOTIF 652..656; /note=LPXTG sorting signal; /evidence=ECO:0000255|PROSITE-ProRule:PRU00477 |
| Gene Encoded By | |
| Mass | 74,768 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.46; |