| IED ID | IndEnz0002010517 |
| Enzyme Type ID | protease010517 |
| Protein Name |
Transglutaminase-activating metalloprotease TAMEP TGase-activating protease EC 3.4.-.- Transglutaminase-activating metalloproteinase |
| Gene Name | |
| Organism | Streptomyces mobaraensis (Streptoverticillium mobaraense) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Streptomycetales Streptomycetaceae Streptomyces Streptomyces mobaraensis (Streptoverticillium mobaraense) |
| Enzyme Sequence | MRPTPQRRAVATGALVAVTAMLAVGVQTTSANAGQDKAAHPAPRQSIHKPDPGAEPVKLTPSQRAELIRDANATKAETAKNLGLGAKEKLVVKDVVKDKNGTLHTRYERTYDGLPVLGGDLVVDATRSGQVKTAAKATKQRIAVASTTPSLAASAAEKDAVKAARAKGSKAGKADKAPRKVVWAAKGTPVLAYETVVGGVQDDGTPSQLHVITDAKTGKKLFEFQGVKQGTGNSQHSGQVQIGTTKSGSSYQMNDTTRGGHKTYNLNHGSSGTGTLFTDSDDVWGNGTNSDPATAGVDAHYGAQLTWDYYKNVHGRNGIRGDGVGAYSRVHYGNNYVNAFWDDSCFCMTYGDGNGIPLTSIDVAAHEMTHGVTSATANLTYSGESGGLNEATSDMMATAVEFWANNPADPGDYLIGEKININGDGTPLRYMDKPSKDGASKDAWYSGLGGIDVHYSSGPANHWFYLASEGSGPKDIGGVHYDSPTSDGLPVTGVGRDNAAKIWFKALTERMQSNTDYKGARDATLWAAGELFGVNSDTYNNVANAWAAINVGPRASSGVSVTSPGDQTSIVNQAVSLQIKATGSTSGALTYSATGLPAGLSINASTGLISGTPTTTGTSNVTVTVKDSAGKTGSTSFKWTVNTTGGGSVFENTTQVAIPDAGAAVTSPIVVTRSGNGPSALKVDVNITHTYRGDLTIDLVAPNGKTWRLKNSDAWDSAADVSETYTVDASSVSANGTWKLKVQDVYSGDSGTIDKWRLTF |
| Enzyme Length | 760 |
| Uniprot Accession Number | P83543 |
| Absorption | |
| Active Site | ACT_SITE 367; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; ACT_SITE 454; /note=Proton donor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Cleaves the N-terminal propeptide of transglutaminase thus activating it. {ECO:0000269|PubMed:12869197}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Metal binding (3); Propeptide (1); Region (2); Signal peptide (1) |
| Keywords | Direct protein sequencing;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12869197}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 79,181 |
| Kinetics | |
| Metal Binding | METAL 366; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 370; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 390; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |