| IED ID | IndEnz0002010519 |
| Enzyme Type ID | protease010519 |
| Protein Name |
Tk-subtilisin EC 3.4.21.- |
| Gene Name | TK1675 |
| Organism | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) |
| Taxonomic Lineage | cellular organisms Archaea Euryarchaeota Thermococci Thermococcales Thermococcaceae Thermococcus Thermococcus kodakarensis Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) |
| Enzyme Sequence | MKKSIALVLSIVLLAALFAVPASAGEQNTIRVIVSVDKAKFNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKLKKMPGVEKVEFDHQAVLLGKPSWLGGGSTQPAQTIPWGIERVKAPSVWSITDGSVSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGTHVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAILGPDGVADKDGDGIIAGDPDDDAAEVISMSLGGPADDSYLYDMIIQAYNAGIVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPGVDILSTYPDDSYETLMGTSMATPHVSGVVALIQAAYYQKYGKILPVGTFDDISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG |
| Enzyme Length | 422 |
| Uniprot Accession Number | P58502 |
| Absorption | |
| Active Site | ACT_SITE 139; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 177; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 348; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Thermostable. Highly active at 80 degrees Celsius.; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 9.5.; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (23); Chain (1); Domain (1); Helix (15); Propeptide (1); Signal peptide (1); Turn (6) |
| Keywords | 3D-structure;Calcium;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (19) |
| Cross Reference PDB | 2E1P; 2Z2X; 2Z2Y; 2Z2Z; 2Z30; 2Z56; 2Z57; 2Z58; 2ZRQ; 2ZWO; 2ZWP; 3A3N; 3A3O; 3A3P; 3VHQ; 3VV2; 3WIU; 3WIV; 4JP8; |
| Mapped Pubmed ID | 17237225; 17706669; 17988685; 18951896; 19766655; 19813760; 22686281; 23237738; 24115021; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,786 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.B57; |