| IED ID | IndEnz0002010520 |
| Enzyme Type ID | protease010520 |
| Protein Name |
Thiol protease EC 3.4.22.- |
| Gene Name | tpr PG_1055 |
| Organism | Porphyromonas gingivalis (strain ATCC BAA-308 / W83) |
| Taxonomic Lineage | cellular organisms Bacteria FCB group Bacteroidetes/Chlorobi group Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas gingivalis Porphyromonas gingivalis (strain ATCC BAA-308 / W83) |
| Enzyme Sequence | MEKKLVPQSISKERLQKLEAQATLTPQQEEAKARKIEREKARLKELNIPTESKESKDCSPAGMINPYALTEVILERPLDWSNPRTTDIVERVLGSSMQDLSKGDSVLRAGRDQNAEVKIVDSVLTKTQRGQDGLERILESFNDYDMPPEEKEEAAPKAKKAAQKLDIDDLREQALSSTTITKEISKIILPTKNLRDDNNTVHQYREVGFQSNGAHNLWDTVVQGIAGDCYMLAALSAIAWVWPALLNMDVDIMSNQDEWRLYRYFIGRSKQTYARPSGSGTSTNEILQEGYYKVPIFARSRYWFNGEYWPALFEQAYANWKFPNDSKYNAILQIGGGWPEEALCELSGDSWFTSSGKLMLSSFTDLSLLNFMKSMCYSWKTIKPMVIVTPCWEPLPPMMPGIAAYHAYTVLGYTVSNGAYYLIIRNPWGVTEPTGDGVLSKRDWVIHFDNMKWFNLSKDDGIFALRLDKVRENFWYIAYMY |
| Enzyme Length | 481 |
| Uniprot Accession Number | P25806 |
| Absorption | |
| Active Site | ACT_SITE 229; /evidence=ECO:0000250; ACT_SITE 406; /evidence=ECO:0000250; ACT_SITE 426; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Inactive below 20 degrees Celsius and pH 6.0. Inhibited by divalent cations. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease. Probably an important virulence factor. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (1); Sequence conflict (1) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 54,991 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.B8; |