| IED ID | IndEnz0002010521 |
| Enzyme Type ID | protease010521 |
| Protein Name |
Transmembrane protease serine 4 EC 3.4.21.- Channel-activating protease 4 mCAP2 Cleaved into: Transmembrane protease serine 4 catalytic chain |
| Gene Name | Tmprss4 Cap2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MESDSGQPLNNRDIVPFRKPRRPQETFKKVGIPIIAVLLSLIALVIVALLIKVILDKYYFICGSPLTFIQRGQLCDGHLDCASGEDEEHCVKDFPEKPGVAVRLSKDRSTLQVLDAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM |
| Enzyme Length | 435 |
| Uniprot Accession Number | Q8VCA5 |
| Absorption | |
| Active Site | ACT_SITE 243; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 288; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 385; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (By similarity). Seems to be capable of activating ENaC (PubMed:12149280). {ECO:0000250|UniProtKB:Q9NRS4, ECO:0000269|PubMed:12149280}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (2); Disulfide bond (8); Domain (3); Glycosylation (2); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Secreted;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NRS4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NRS4}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 4 catalytic chain]: Secreted {ECO:0000250|UniProtKB:Q9NRS4}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q9NRS4}. |
| Modified Residue | |
| Post Translational Modification | PTM: Proteolytically processed; probably by an autocatalytic mechanism. {ECO:0000250|UniProtKB:Q9NRS4}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16428450; 16524950; 19592578; 20562862; 21267068; 21677750; 21993886; 22944691; 26309024; 26889029; 29529050; 32303635; 32379417; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,496 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |