| IED ID | IndEnz0002010551 |
| Enzyme Type ID | protease010551 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 4 26S proteasome regulatory subunit rpn-10 |
| Gene Name | rpn-10 B0205.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MVQESTMICVDNSEYMRNGDFQPTRLQSQQDAVNLVTQCKLRANPENAVGILSMANSVQVLSSLSTEQGRLMMKNHSIEPFGKCNFIAGIKIAHLALKHRQNRNHKMRVVLFIGSPLEEIEMNELVKIAKKMKKEKVLCDVIMFGENESDGHEKFSTFVDTLNGKEGSGSSLIVVPQGSSLTDALLQSSVCKNEDGQAAFGGGGNGMDNAFGMDVENDPDLALALRVSMEEERARQAAAAAANGGAADSGADAEVAAAAAAVPLEEMDMGAMTEEQQLEWALRLSMQENAPAEQPQVQHEQMDVDGAPAVGGDNLDDLMNNPELLQQIVDDLPAANAEKDDDKEKK |
| Enzyme Length | 346 |
| Uniprot Accession Number | O61742 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression (PubMed:20453865, PubMed:22105480, PubMed:26828939). Involvement in UBS might be cell type specific (PubMed:20453865). Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity (PubMed:26828939). Required for fertility, sperm production, and sex determination through regulation of tra-2 protein (PubMed:17050737). Plays a role in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480). {ECO:0000250|UniProtKB:P55036, ECO:0000269|PubMed:17050737, ECO:0000269|PubMed:20453865, ECO:0000269|PubMed:22105480, ECO:0000269|PubMed:26828939}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (3); Region (1) |
| Keywords | Cytoplasm;Nucleus;Proteasome;Reference proteome;Repeat |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26828939}. Nucleus {ECO:0000269|PubMed:26828939}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 11559592; 11778048; 12679813; 16710447; 17392428; 17825049; 18471277; 18842813; 19123269; 21085631; 21177967; 21367940; 22267497; 22560298; 22768338; 23800452; 24884423; 25487147; 26351692; 30036395; 30140741; 31283754; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 37,348 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |