| IED ID | IndEnz0002010561 |
| Enzyme Type ID | protease010561 |
| Protein Name |
Presenilin-A PS-A EC 3.4.23.- |
| Gene Name | psenA DDB_G0291352 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MKENEDEINKTDEKYKIKNPSNNGNNKNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGNSNLENIEGLNKYNIYKKKKGKNESNTSLNNIYISSPNLSERSDNSIGSYCTNKTMKSENSIINIETLFRDSVSEQNSDECGSKVDKDLDEDDDDDDDETEVPELVDYSEMIVSILYPVCITMVIVVLAIRAISSSTSKNSQIVEISNDNSGGNGDSSSGADKMVFDSVVNSLIFLAVIILSTTIMVVLYKFKLMKALYAWLMGTSILLLGVFGGFLFLILLAYLNLGLDYVTFVIVVWNFSVGGIVCIFWYSPKLLNQGYLISISVLMALFFSRLPDWTTWGILSIVSIYDIFAVLCPGGPLRILIETAQKRNENIPAMIYNASIYIGMIYNEDNLENNNNNNNNNNIELNINEVDIENNNNNEDENKNNTEDGNNNNNKNKNNNNNNNNRIENENGAENSSENGSITPPPTIPNFIKDEKEINRSSGSNGFPNFKKCANDNILIGDAETNDEIVSNAESSIDSTISESYVKPKQSIRLGLGDFVFYSVLIGKAASYQITTVFTVFIAIITGLFLTLILLAVFRRALPALPMSIIFGIIVFFLTFKILIQYIYFLGENQIFV |
| Enzyme Length | 622 |
| Uniprot Accession Number | Q54ET2 |
| Absorption | |
| Active Site | ACT_SITE 351; /evidence=ECO:0000250; ACT_SITE 543; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (4); Intramembrane (1); Motif (1); Region (3); Topological domain (10); Transmembrane (8) |
| Keywords | Endoplasmic reticulum;Golgi apparatus;Hydrolase;Membrane;Notch signaling pathway;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15507682; 20699477; 22489754; 23504135; 24161926; 24463814; 27079701; |
| Motif | MOTIF 588..590; /note=PAL |
| Gene Encoded By | |
| Mass | 69,503 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |