| IED ID | IndEnz0002010654 |
| Enzyme Type ID | protease010654 |
| Protein Name |
Metacaspase III c PtMCA-IIIc EC 3.4.22.- Cleaved into: Small subunit p10; Large subunit p20 |
| Gene Name | MCA-IIIc PHATRDRAFT_54873 |
| Organism | Phaeodactylum tricornutum (strain CCAP 1055/1) |
| Taxonomic Lineage | cellular organisms Eukaryota Sar Stramenopiles Ochrophyta Bacillariophyta (diatoms) Bacillariophyceae (Raphid pennate diatoms) Bacillariophycidae Naviculales Phaeodactylaceae Phaeodactylum Phaeodactylum tricornutum (Diatom) Phaeodactylum tricornutum (strain CCAP 1055/1) |
| Enzyme Sequence | MGFLRRQLREQFEKKKPEALQADIRMISGCQDVQTSADVSNVSSFQLPDPAGNAGGACTSTLLNVLYKDHQTPEDTMSFVELLNKMRENLEAKGFSQVPQLTASHPIDVNDDFDLVPPAATGTRRALLIGINYVGHEQGVLRGCHNDVKNMVEYIKAVHGFEDENITILMDDGEHTAPTHANMIAAYKKIVALSKADDALFCHFSGHGAKIRDDDRGEEDDGYDETLVPIDYHENGMIRDDDLYDILIKPLVQGVHLVCLMDCCHSGTVLDLPYVYKADGNFTEMEIDENFDFKKLLGKFGIDDFDKFGGEALGKINGDALGKVGKDALGKLNKFFG |
| Enzyme Length | 337 |
| Uniprot Accession Number | B7G6D3 |
| Absorption | |
| Active Site | ACT_SITE 207; /evidence=ECO:0000250|UniProtKB:Q08601; ACT_SITE 264; /evidence=ECO:0000250|UniProtKB:Q585F3 |
| Activity Regulation | ACTIVITY REGULATION: Activated by Ca(2+). {ECO:0000269|PubMed:34566902}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cysteine protease that cleaves specifically after arginine residues. {ECO:0000269|PubMed:34566902}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (3); Disulfide bond (1); Metal binding (4); Modified residue (1); Mutagenesis (3); Propeptide (3) |
| Keywords | Autocatalytic cleavage;Calcium;Disulfide bond;Hydrolase;Metal-binding;Oxidation;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 202; /note=Cysteine sulfenic acid (-SOH); /evidence=ECO:0000269|PubMed:34566902 |
| Post Translational Modification | PTM: Auto-proteolytic cleavage into a large and a small subunit which probably remain associated by non-covalent bonds. {ECO:0000269|PubMed:34566902}.; PTM: Following oxidative stress, the oxidation of Cys-202 leads to the formation of a disulfide bond between Cys-202 and Cys-259 which enhances catalytic activity. {ECO:0000269|PubMed:34566902}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 37,250 |
| Kinetics | |
| Metal Binding | METAL 224; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3; METAL 240; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3; METAL 241; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3; METAL 271; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3 |
| Rhea ID | |
| Cross Reference Brenda |