| IED ID | IndEnz0002010669 |
| Enzyme Type ID | protease010669 |
| Protein Name |
Presenilins-associated rhomboid-like protein, mitochondrial EC 3.4.21.105 Mitochondrial intramembrane-cleaving protease Parl Rhomboid-7 |
| Gene Name | rho-7 Parl R7 CG8972 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MLMSRALCRSWLPQVARRCHANVNVPILRINSGHPAARSCRQIHSNRKQSSNLKPTTGEPAAAEQNTPVPVNNVIKAVAFTGAFTVGCFAGATILEYENTRSLILEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWRVPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAVSLGKEQFLAVYLSAGVFSSLMSVLYKAATSQAGMSLGASGAIMTLLAYVCTQYPDTQLSILFLPALTFSAGAGIKVLMGIDFAGVVMGWKFFDHAAHLGGAMFGIFWATYGAQIWAKRIGLLNYYHDLRRTKQK |
| Enzyme Length | 351 |
| Uniprot Accession Number | A1Z8R8 |
| Absorption | |
| Active Site | ACT_SITE 256; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:P20350; ACT_SITE 314; /evidence=ECO:0000250|UniProtKB:P20350 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Evidence={ECO:0000250|UniProtKB:P20350}; |
| DNA Binding | |
| EC Number | 3.4.21.105 |
| Enzyme Function | FUNCTION: Mitochondrial intramembrane protease which plays a critical role in the regulation of mitochondrial function (PubMed:16713954, PubMed:21945938). Essential for mitochondrial development and fusion during spermatogenesis and the development of neurons and muscles (PubMed:16713954, PubMed:21945938). Essential for proteolytic processing of Pink1 and HtrA2 into their mature forms (PubMed:19048081). May also be involved, but not required, for the proteolytic processing of Opa1 (PubMed:19048081, PubMed:21945938). {ECO:0000269|PubMed:16713954, ECO:0000269|PubMed:19048081, ECO:0000269|PubMed:21945938}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous initiation (1); Region (1); Topological domain (8); Transit peptide (1); Transmembrane (7) |
| Keywords | Hydrolase;Membrane;Mitochondrion;Mitochondrion inner membrane;Reference proteome;Transit peptide;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:16713954}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10887159; 11023685; 12169630; 17114579; 20220848; 20371351; 21074052; 21512585; 23071443; 23087837; 24099009; 24101729; 24874806; 24952591; 24998521; 25062361; 25312911; 26613727; 27502471; 31794428; 32958650; 33590535; 33827210; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,932 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |