| IED ID | IndEnz0002010731 |
| Enzyme Type ID | protease010731 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase A EC 3.4.19.12 Deubiquitinating enzyme A Ubiquitin thioesterase A Ubiquitin-specific-processing protease A |
| Gene Name | ubpA usp5 DDB_G0291239 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MELFPELKNIKVPTEKSRLWKDECCYCFDTPENGEGLFIDLIGLLAFSKKYVQLNHQKTHHHLYLNFKKVAIVNEKVKSPTIENGGEEKPPKKLAIGVEGGFNVEDEEIKYEEHYKLYIFPDDKFLELSDPIIPENVRVCCEKIKTLNSQSRKEEIVSWNAESVFPSAFAESIIQLDNNTKKIDPKGPWRCDIEGCDKVENLWLNLTDGFIGCGRKYADGTGGNGHAQEHFNQTQYPISVKLGTITKDHADVYSYPEDDMVSDPLLFQHLTHWGLNPNVMVKTEKSMAELELDQNLNFEFGKIQEKGKLLENVFGPGLTGIENLGNSCYMSSVIQMIFAIDSFQTRYLKDREASFKDITQDPTQSFEIQMSKLAHGLLSGDYSIPLSKPSKNANEESEAATQIGIAPKMFKSLIGASHAEFSTMKQQDAHEYLQYLLEYIERAEHSRPSWIQQANPTRLFQFHNEDRIECGSSGQVKYTRRLENILSVPVNLDDATNKQEVAQYEETLKQQNGVRQKDQEEIRPIIPLVSCINGFVEPYRVEDFLSPATGVKTFSLNSSRMATFPEVLIIHLKKYTYNADYTPKKLNVFMDVPDIIDIDSLRGRGIKEGEVPLKEGTINTTTKVPEPSFNQEVLDTLLSMDFPLVRCKKALLATGGKDAELAMNWIFEHTEDPDIDIEQTPVNNNNNNNNSSNSNDKLFVFNSQDVDNIIGMGFTDSQAKLALKNTKGNLERAADWLFSHIDNLDELVAKDNASTSSINPSLIPQSTTSLQPVSDGVGKYELLGFISHLGNNVTCGHYVCHIKKNNRWIKFNDRHVQLSEQPPKELGYIYFYKRQLN |
| Enzyme Length | 837 |
| Uniprot Accession Number | P54201 |
| Absorption | |
| Active Site | ACT_SITE 328; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 797; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Required for development but not growth. {ECO:0000269|PubMed:9786928}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Domain (3); Erroneous gene model prediction (1); Region (1); Sequence conflict (2); Zinc finger (1) |
| Keywords | Hydrolase;Metal-binding;Protease;Reference proteome;Repeat;Thiol protease;Ubl conjugation pathway;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17878305; 19387798; |
| Motif | |
| Gene Encoded By | |
| Mass | 94,966 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |