| IED ID | IndEnz0002010733 |
| Enzyme Type ID | protease010733 |
| Protein Name |
Ubiquitin-like protease 2 EC 3.4.22.- |
| Gene Name | ulp-2 Y38A8.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MSDSTQMEANAAINEIKKRTRKLDQSLQMRFCADQFFIGNHCTKLASGKSIIISQNSKNRICLRFFMAADPLVGYTGRDFGIAFNQIDHISLKDEQQENPAVLICTLNLSSYTKMCKLQTGLKDVVEKPFLYNKSLARNLTFILKPWNDDPDTFVKISYNDEHREYVHSYDYDVAKSLMFKEVQAVWEQSLKEQLQRRHQTGRVYLTSQLSEMTPREWVQFLADQKLSKIVCHNGSIQYARVEDNPHGRKHTAVATNGFDHRGTRVLNSFGKAHASLATQEKSYAKKRKLTEQSLKLIYRNDRSVWLEGSCAKNLKMPKINSEPNMGEFMGWPDMDNAMTHPTSNFENEDVMKSTKQPNDFVSFEQLQAPPPVLQRQNGAIYSTQSVAFTHISGNDGVEDLTEKISHLGEEAYNIDMANALHAFSDNWHYEIHPNTVHNASFEQLHIGDGNSSIGTIGFNPLEPYPQSSFPQSNNWQQAHGDFTFPQVSFPNTQQGSCLPSTPTAALPPTRPVVEKIPPDTQLFTFPPSGSCTTGMDPVVLLVKDIKTLDRKEFLNDSVMAFMLNYIAFMLSSELMKSVHMCNTFLFVNLTRLLPPLCFSKRRPIEPEHIKIVKDNCPRVLRWTRKFDVLAKDYIIIPINEDLHWLVIAVINPSGAIVDMSNEEASRAAPKCYIVFFDPLSGLDPSKKNHMCHCIKIYLAQLYENTKAPGMKFASKNPTIYDEERVVVTRAENTPIQDNFYDCGLYVLHFIEGLFCYPNRPVNVNDFPNFDWSKFFPEANKMCDLMRDKVYNLILQQADKPARSRLAKFERENKCGLSREGALRKARRHSAVNERRTKRHRDYYARHYSLSPPHRNVMNDDPTFMNPRGLAEMPITRLVRRLRIPEDNFPIAY |
| Enzyme Length | 893 |
| Uniprot Accession Number | Q23238 |
| Absorption | |
| Active Site | ACT_SITE 644; /evidence=ECO:0000250|UniProtKB:Q02724; ACT_SITE 678; /evidence=ECO:0000250|UniProtKB:Q02724; ACT_SITE 743; /evidence=ECO:0000305|PubMed:26412237 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Protease that catalyzes two essential functions in the smo-1 pathway: processing of full-length smo-1 to their mature forms and deconjugation of smo-1 from targeted proteins (By similarity). May deconjugate smo-1 from the cadherin protein hmr-1 and plays a role in its recruitment to and the maintenance of adherens junctions (PubMed:26412237). Required for epidermal morphogenesis during embryonic development (PubMed:26412237). {ECO:0000250|UniProtKB:Q8RWN0, ECO:0000269|PubMed:26412237}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Mutagenesis (1); Region (1) |
| Keywords | Cytoplasm;Developmental protein;Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26412237}. Cytoplasm, cytosol {ECO:0000269|PubMed:26412237}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 12529635; 14551910; 15084750; 15791247; 17392428; 17417969; 18182484; 18829898; 20351174; 21085631; 21177967; 22267497; 22286215; 22500807; 22560298; 22634595; 22768338; 23637632; 23800452; 24884423; 25475837; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 102,426 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |