| IED ID | IndEnz0002010788 |
| Enzyme Type ID | protease010788 |
| Protein Name |
Presenilin-2 PS-2 EC 3.4.23.- Presenilin beta PS-beta |
| Gene Name | psen2 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MIKLSDSEDEECNERTSLITSESPPLPSYQDGVQASEGLETSYHRERQPDSTQNNEDVPNGRTSGADAYNSETTVENEEEELTLKYGARHVIMLFVPVTLCMVVVVATIKSVSFYTEKDGQLIYTPFSEDTTSVGERLLNSVLNTLIMISVILVMTIFLVLLYKYRCYKFIHGWLILSSLMLLFMFTYIYLSEVFKTYNIAMDYPTLFMVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLLAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMMWTVGMADSATADGRMNQQVQHIDRNTPEGANSTVEDAAETRIQTQSNLSSEDPDEERGVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNIVRPFMDTLASHQMYI |
| Enzyme Length | 449 |
| Uniprot Accession Number | O12977 |
| Absorption | |
| Active Site | ACT_SITE 266; /evidence=ECO:0000250; ACT_SITE 367; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (By similarity). May play a role in negative regulation of apoptotic cascades during oogenesis and embryogenesis, and in developmentally matured tissues such as brain tissue. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (3); Glycosylation (1); Intramembrane (1); Motif (1); Region (1); Topological domain (10); Transmembrane (8) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Notch signaling pathway;Protease;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 415..417; /note=PAL |
| Gene Encoded By | |
| Mass | 50,274 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |