| IED ID | IndEnz0002010809 |
| Enzyme Type ID | protease010809 |
| Protein Name |
Serpin B7 Megsin TP55 |
| Gene Name | SERPINB7 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MASLAAANAEFCFNLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLSVIEDPSMKILELRYNGGINMYVLLPENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDIFDESKADLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGSNIVEKQLPQSTLFRADHPFLFVIRKDDIILFSGKVSCP |
| Enzyme Length | 380 |
| Uniprot Accession Number | O75635 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Modified residue (2); Natural variant (1); Sequence conflict (1); Site (1) |
| Keywords | Alternative splicing;Cytoplasm;Palmoplantar keratoderma;Phosphoprotein;Protease inhibitor;Reference proteome;Serine protease inhibitor |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | MOD_RES 217; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:20068231; MOD_RES 223; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:20068231 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12386281; 12397041; 15213261; 15788472; 16431886; 16550745; 16796905; 18471408; 18498720; 18580857; 18793525; 20628624; 24514002; 24575807; 24773080; 24954659; 25007157; 25940237; 26763456; 27666198; 27786350; 28211129; 29106929; 30592269; 31706940; 32406097; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,905 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |