| IED ID | IndEnz0002010813 |
| Enzyme Type ID | protease010813 |
| Protein Name |
STAM-binding protein-like A EC 3.4.19.- |
| Gene Name | stambpa amsh stambp |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MSEHTDCSVSSEDRVRALTKLGSSVDVSEDVPPRRYFRSGMEIIRMANIYADEGNVEHAFILYNKYITLFIEKLPKHREYKTANIPEKKETMRKLKEIAFPKAEELKKLLLKQYDKEHAEYLVRKRAEDAARAVEMLKQQEQEAQRQRLAELQQRQREQEQFSAFEEMIRRQELEKERRRIVQEFSIPVSPTAPDVLLPDVHGPPQASLSPQTPPAGATNHQGLPAFDRSLKPSVPVSAGHSALVNGLRQLFVPAELCQRFLKLAETNTARAVETCGILCGKLMKNAFTVTHVIVPKQCGGPDYCDTENEEELFLIQDQNDLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFNETGYFRLTDYGMDDVGTCKQRGFHPHPKDPPLFAASHHVSITDGSVTMLDLR |
| Enzyme Length | 418 |
| Uniprot Accession Number | Q6TH47 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.19.- |
| Enzyme Function | FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (7); Motif (1); Region (1); Sequence conflict (4); Site (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Ubl conjugation pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 329..342; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 47,510 |
| Kinetics | |
| Metal Binding | METAL 329; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 331; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 342; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 344; /note=Zinc 2; /evidence=ECO:0000250; METAL 384; /note=Zinc 2; /evidence=ECO:0000250; METAL 390; /note=Zinc 2; /evidence=ECO:0000250; METAL 392; /note=Zinc 2; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |