| IED ID |
IndEnz0002010816 |
| Enzyme Type ID |
protease010816 |
| Protein Name |
Streptokinase C
|
| Gene Name |
skc |
| Organism |
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Firmicutes
Bacilli
Lactobacillales
Streptococcaceae
Streptococcus
Streptococcus dysgalactiae group
Streptococcus dysgalactiae
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
|
| Enzyme Sequence |
MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDISLKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKADLLKAIQEQLIANVHSNDDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRPYKEKPIQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYRVKNREQAYRINKKSGLNEEINNTDLISEKYYVLKKGEKPYDPFDRSHLKLFTIKYVDVDTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK |
| Enzyme Length |
440 |
| Uniprot Accession Number |
P00779 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (25); Chain (1); Helix (5); Natural variant (2); Sequence conflict (2); Signal peptide (1); Turn (4) |
| Keywords |
3D-structure;Direct protein sequencing;Plasminogen activation;Signal;Virulence |
| Interact With |
P00747 |
| Induction |
|
| Subcellular Location |
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| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..26; /evidence=ECO:0000269|PubMed:6760891 |
| Structure 3D |
X-ray crystallography (4) |
| Cross Reference PDB |
1BML;
1L4D;
1L4Z;
1QQR;
|
| Mapped Pubmed ID |
12456874;
9733510;
|
| Motif |
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| Gene Encoded By |
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| Mass |
50,140 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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