| IED ID |
IndEnz0002010828 |
| Enzyme Type ID |
protease010828 |
| Protein Name |
Tsetse thrombin inhibitor
|
| Gene Name |
TTI |
| Organism |
Glossina morsitans morsitans (Savannah tsetse fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Calyptratae
Hippoboscoidea
Glossinidae
Glossina (tsetse flies)
Glossina
Glossina morsitans
Glossina morsitans morsitans (Savannah tsetse fly)
|
| Enzyme Sequence |
MKFFTVLFFLLSIIYLIVAAPGEPGAPIDYDEYGDSSEEVGGTPLHEIPGIRL |
| Enzyme Length |
53 |
| Uniprot Accession Number |
O97373 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Potent and specific inhibitor of human thrombin. It is also a potent inhibitor of thrombin-induced platelet aggregation. It is capable of antagonizing host hemostasis and facilitating blood feeding. {ECO:0000269|PubMed:8644901}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (1); Chain (1); Helix (1); Signal peptide (1) |
| Keywords |
3D-structure;Direct protein sequencing;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D |
X-ray crystallography (6) |
| Cross Reference PDB |
6TKG;
6TKH;
6TKI;
6TKJ;
6TKL;
7PHX;
|
| Mapped Pubmed ID |
33096052;
34596182;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
5,800 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|