| IED ID | IndEnz0002010871 |
| Enzyme Type ID | protease010871 |
| Protein Name |
Zinc metalloproteinase oxiagin EC 3.4.24.- Snake venom metalloprotease SVMP Fragment |
| Gene Name | |
| Organism | Naja oxiana (Central Asian cobra) (Oxus cobra) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Elapidae Elapinae Naja Naja oxiana (Central Asian cobra) (Oxus cobra) |
| Enzyme Sequence | TNTPEQQCYLQAKCYIEFYVVV |
| Enzyme Length | 22 |
| Uniprot Accession Number | P0DJJ4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom metalloproteinase that inhibits the classical complement pathway dose-dependently. It acts by binding to carbohydrates of IgG within the antibody-sensitized sheep erythrocytes (EA) complex, and thus prevents interaction of component C2 with immobilized C4b. Also induces cation-independent hemagglutination that can be prevented by D-galactose pretreatment. {ECO:0000269|PubMed:15829304}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Domain (1); Non-terminal residue (1) |
| Keywords | Cell adhesion impairing toxin;Complement system impairing toxin;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,640 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |