| IED ID | IndEnz0002010887 |
| Enzyme Type ID | protease010887 |
| Protein Name |
Snake venom metalloproteinase hemorrhagic factor 2 SVMP EC 3.4.24.- Hemorrhagic factor II LHF-II |
| Gene Name | |
| Organism | Lachesis muta muta (Bushmaster) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Lachesis Lachesis muta (South American bushmaster) Lachesis muta muta (Bushmaster) |
| Enzyme Sequence | FSQKYIELVVVADHGMFTKYNGNLNTIRTRVHEIVNTLNGFYRSLNILISLTDLEIWSNQDLINVQSAANDTLKTFGEWRERVLLNRISHDNAQLLTAIDLADNTIGIAYTGGMCYPKNSVGIVQDHSPKTLLIAVTMAHELGHNLGMKHDENHCHCSASFCIMPPSISEGPSYEFSDCSKDYYQMFLTKRKPQCILNKP |
| Enzyme Length | 200 |
| Uniprot Accession Number | P22796 |
| Absorption | |
| Active Site | ACT_SITE 141; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom zinc metalloproteinase that induces hemorrhage. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (1); Metal binding (7); Natural variant (1) |
| Keywords | Calcium;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemorrhagic toxin;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 22,596 |
| Kinetics | |
| Metal Binding | METAL 7; /note=Calcium; /evidence=ECO:0000250; METAL 91; /note=Calcium; /evidence=ECO:0000250; METAL 140; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 144; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 150; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 195; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 198; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.B37; |