| IED ID | IndEnz0002010901 |
| Enzyme Type ID | protease010901 |
| Protein Name |
Putative zinc metalloprotease TP_0600 EC 3.4.24.- |
| Gene Name | TP_0600 |
| Organism | Treponema pallidum (strain Nichols) |
| Taxonomic Lineage | cellular organisms Bacteria Spirochaetes Spirochaetia Spirochaetales Treponemataceae Treponema Treponema pallidum Treponema pallidum subsp. pallidum (syphilis treponeme) Treponema pallidum (strain Nichols) |
| Enzyme Sequence | MIKIIIGVVVLGIVVLFHELGHFVAALWCRVEVLSFSVGMGPVLFRKKFGKTEYRLSMLPLGGYCGMKGEQAFQTALDQKLSRIPVEPGSLYAVGPLKRMGIAFAGPLANVLMAVMVLALVSALGSRVHTFGNRISPVYVYDSSDNSPARRVGLQDGDTILRIGDQPIRYFSDIQKIVSQHAQRALPFVIERRGQLMHVTITPDRDAHTGMGRVGIYHYVPLVVAAVDAHGAASRAGLEPEDKILAVAGRRVQHAVQLLALLKEFRKKSVVLTVLRSGKRRYHTIALVRTENGAIDVGIEWKAHTVVIPGTSFFASVRAGIAETLRMCVLTVKGIGMLFRGLQFQQAISGPLRITHVIGDVAQHGFQESFLTGLSQLCEFVALVCVSLFIMNLLPIPILDGGLILFACVELFMQRSIHPRVLYYLQFVGFAFVALIFLCAFWNDVNFLFH |
| Enzyme Length | 450 |
| Uniprot Accession Number | O83609 |
| Absorption | |
| Active Site | ACT_SITE 19; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Domain (1); Metal binding (2); Transmembrane (3) |
| Keywords | Cell inner membrane;Cell membrane;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18509523; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,565 |
| Kinetics | |
| Metal Binding | METAL 18; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 22; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |