| IED ID | IndEnz0002010946 |
| Enzyme Type ID | protease010946 |
| Protein Name |
RHOMBOID-like protein 1 AtRBL1 EC 3.4.21.- |
| Gene Name | RBL1 At2g29050 T9I4.13 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MARDRREGLEIKVVNPPAAATNNVAVETSPATATRRRRQQQRASFAEFRPFKLWFPWLVPAIVVANIALFAISMFINNCPKNSAYCLARFLGRFAFQPMKENPLLGPSSLTLEKMGALDVSMVVHKHEVWRLFTCIWLHAGVFHVLANMLSLIFIGIRLEQEFGFVRIGLLYMISGFGGSLLSSLFNRAGISVGASGALFGLLGAMLSELLTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIRPQYGYFNQRNNPRGYAAPSAKSKHKPYQYVLWITSLVLLIAGYTAGLVVLLRGTDLNKHCSWCHYLSCIPTSLWSCKSQNVYCESSQIGQQMNLTCITNGKTEMYKLSNDIPSRIQQLCSQLCR |
| Enzyme Length | 389 |
| Uniprot Accession Number | Q0WQX7 |
| Absorption | |
| Active Site | ACT_SITE 196; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:P54493; ACT_SITE 248; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P54493 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. Unable to cleave the Drosophila protein Spitz. {ECO:0000269|PubMed:16223493}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (3); Chain (1); Erroneous gene model prediction (1); Transmembrane (7) |
| Keywords | Alternative splicing;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16223493}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16607029; 18543065; 18775970; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,360 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |