| IED ID | IndEnz0002010952 |
| Enzyme Type ID | protease010952 |
| Protein Name |
Snake venom metalloproteinase bothrolysin SVMP EC 3.4.24.50 Hemorrhagic metalloproteinase J Zinc metalloproteinase bothrolysin Fragment |
| Gene Name | |
| Organism | Bothrops jararaca (Jararaca) (Bothrops jajaraca) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops jararaca (Jararaca) (Bothrops jajaraca) |
| Enzyme Sequence | TPEHQRYIELFLVVDSGMFMKYNGNSDKI |
| Enzyme Length | 29 |
| Uniprot Accession Number | P20416 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleavage of 4-Gln-|-His-5, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 of insulin B chain and Pro-|-Phe of angiotensin I.; EC=3.4.24.50; |
| DNA Binding | |
| EC Number | 3.4.24.50 |
| Enzyme Function | FUNCTION: Snake venom zinc metalloproteinase that impairs hemostasis in the envenomed animal. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (1); Non-terminal residue (1) |
| Keywords | Calcium;Direct protein sequencing;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 3,433 |
| Kinetics | |
| Metal Binding | METAL 9; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |