| IED ID | IndEnz0002010999 |
| Enzyme Type ID | protease010999 |
| Protein Name |
Proteinase-activated receptor 3 PAR-3 Coagulation factor II receptor-like 2 Thrombin receptor-like 2 |
| Gene Name | F2rl2 Par3 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MEMKVLILVGVRLLFLPTTVCQSGMKHVSDNSALTAESFNGNEHSFEEFPLSDIEGWTGATTTIKAKCPEESITTLHVNNATMGYLRSSLSTKVIPAIYILVFVIGVPANIVTLWKLSSRTKSICLVIFHTNLAIADLLFCVTLPFKIAYHLNGNDWVFGEVMCRVTTVAFYGNMYCAILILTCMGINRYLATVHPFTYRKLPKRNFTLLMCGVVWVMVVLYMLPLAILKQEYHLVQPGITTCHDVHDTCESPLPFQFYYFVSLAFFGFLIPFVVSVFCYTTLIHKLNAQDRKWLRYIKAVLLILVIFTICFAPTNIILIIHHANYYYSNTDSLYFMYLIALCLGSLNSCLDPFLYFIMSKIVDQLTS |
| Enzyme Length | 368 |
| Uniprot Accession Number | Q920E1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Glycosylation (1); Propeptide (1); Signal peptide (1); Site (1); Topological domain (8); Transmembrane (7) |
| Keywords | Blood coagulation;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Hemostasis;Membrane;Receptor;Reference proteome;Signal;Transducer;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
| Modified Residue | |
| Post Translational Modification | PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12836167; 17476308; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,796 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |