| IED ID | IndEnz0002011021 |
| Enzyme Type ID | protease011021 |
| Protein Name |
Probable threonine protease PRSS50 EC 3.4.25.- Serine protease 50 Testis-specific protease-like protein 50 |
| Gene Name | Prss50 Tsp50 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEPWCGAEVRGQGPQGPRVPGASRSRSRALLLLLLLLLLLLPRRPAGERIRPRRPPRHAHPRPPLTRWRPSTGYLAAGASPGTLSTTVPTGPGVSCGSRGICPSGRLRLPRQAQTNQTTTAPPNSQTMAPLKTVGTLGMMDTTGSVLKTVHSSNLPFCGSSHEPDPTLRDPEAMTRRWPWMVSVQANGSHICAGILIASQWVLTVAHCLSQNHVNYIVRAGSPWINQTAGTSSDVPVHRVIINHGYQPRRYWSWVGRAHDIGLLKLKWGLKYSKYVWPICLPGLDYVVEDSSLCTVTGWGYPRANGIWPQFQSLQEKEVSILNSKKCDHFYHKFSRISSLVRIINPQMICASDNNREEFCYEITGEPLVCSSDGTWYLVGMMSWGPGCKKSEAPPIFLQVSYYRPWIWDRLSGEPLALPAPSRTLLLAFLLLLILLGTL |
| Enzyme Length | 439 |
| Uniprot Accession Number | Q8BLH5 |
| Absorption | |
| Active Site | ACT_SITE 207; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 260; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 364; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.25.- |
| Enzyme Function | FUNCTION: May be involved in proteolysis through its threonine endopeptidase activity. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (3); Disulfide bond (4); Domain (1); Glycosylation (3); Region (2); Sequence conflict (4); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Threonine protease;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..47; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14610273; 15491742; 17219777; 18662669; 21086474; 21267068; 21385156; 21659515; 21677750; 25857663; 29842883; 33913480; |
| Motif | |
| Gene Encoded By | |
| Mass | 48,676 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |