| IED ID |
IndEnz0002011038 |
| Enzyme Type ID |
protease011038 |
| Protein Name |
Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B4 chain
|
| Gene Name |
|
| Organism |
Bungarus multicinctus (Many-banded krait) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Sauropsida
Sauria (diapsids)
Lepidosauria (lepidosaurs)
Squamata (squamates)
Bifurcata (split-tongued squamates)
Unidentata
Episquamata
Toxicofera
Serpentes (snakes)
Colubroidea
Elapidae
Bungarinae
Bungarus
Bungarus multicinctus (Many-banded krait)
|
| Enzyme Sequence |
MSSGGLLLLLGLLTLCAELTPVSSRKRHPDCDKPPDTKICQTVVRAFYYKPSAKRCVQFRYGGCNGNGNHFKSDHLCRCECLEYS |
| Enzyme Length |
85 |
| Uniprot Accession Number |
Q1RPT0 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Beta-bungarotoxins are presynaptic neurotoxins of the venom. The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and blocks voltage-gated potassium channels (Kv) (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (4); Domain (1); Signal peptide (1) |
| Keywords |
Disulfide bond;Ion channel impairing toxin;Neurotoxin;Potassium channel impairing toxin;Presynaptic neurotoxin;Secreted;Signal;Toxin;Voltage-gated potassium channel impairing toxin |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..24; /evidence=ECO:0000250 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
9,499 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|