| IED ID | IndEnz0002011050 |
| Enzyme Type ID | protease011050 |
| Protein Name |
Putative ubiquitin thioesterase 232R EC 3.4.19.12 |
| Gene Name | IIV6-232R |
| Organism | Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) |
| Taxonomic Lineage | Viruses Varidnaviria Bamfordvirae Nucleocytoviricota Megaviricetes Pimascovirales Iridoviridae Betairidovirinae Iridovirus (small iridescent insect viruses) Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) |
| Enzyme Sequence | MNNNQCMRKKLDELRNIARSYNISITGKKKQQLCDEIIDYQKNNPPRRSPSPRRSPSPRRISPECEQWLANKGINPRTGKAIKIGGPTYKKLEMECKEASPKIPSPVRQPSPVHSPVRSPVRQPSPVRFVEKTKGALNKMKKDQLIDFAQSLGLNPGKLLKPALVDLIFVNQKPPRRSPSPRRSPSPRRSPSPRRSPSPRPVFVEKTKGALNKMKKDQLIDLAQSLGLNPGKLLKPALVDLIFVNQKPVEPIRASSSSRSSRSTRRSSSTKPSRRSSSRSRRSSSRSRRSSSRSRRSSSRSRRSSRRSTSRSRSLSKRSIRNISTVGDLEDLVASNLPIAIPESLSRSLSPSRTDFHEAEIELGSDFDLNNLPENRIAELKQLNVLAKQNGFRMINVPLDGNCMFSVIGRAFNTSSSVIRQHTVDYLRRCKGSFDHIPANIDDPTINWNDYIDRLEEDACWGDNTALFAASLALNFQAHILQVAGGDEGSWIRFGVNETNMGRIVNMGYLDNFHYIALEPFSGRLDILSIPSTHSKCPPPEISNRRDEEIRRDEEVEDEVIGERIVREAEVIERELRQEEELTSIVSTKRSLRPSIPPKISTEHRRTPKLRPSVPRPSSIRQSQPNVAALARLETLTKIKDIIDALQRPLENKLSTLTNTEKAIMQCIGVA |
| Enzyme Length | 671 |
| Uniprot Accession Number | Q91FU0 |
| Absorption | |
| Active Site | ACT_SITE 400; /evidence=ECO:0000250|UniProtKB:Q96FW1; ACT_SITE 403; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q5VVQ6; ACT_SITE 514; /evidence=ECO:0000250|UniProtKB:Q5VVQ6 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q5VVQ6}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (4); Domain (1); Region (5) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 75,605 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |