| IED ID | IndEnz0002011072 |
| Enzyme Type ID | protease011072 |
| Protein Name |
Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor 1 TNF-R1 Tumor necrosis factor receptor type I TNF-RI TNFR-I p55 p60 CD antigen CD120a |
| Gene Name | Tnfrsf1a Tnfr-1 Tnfr1 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MGLPIVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDNLCPQGKYAHPKNNSICCTKCHKGTYLVSDCPSPGQETVCEVCDKGTFTASQNHVRQCLSCKTCRKEMFQVEISPCKADMDTVCGCKKNQFQRYLSETHFQCVDCSPCFNGTVTIPCKEKQNTVCNCHAGFFLSGNECTPCSHCKKNQECMKLCLPPVANVTNPQDSGTAVLLPLVIFLGLCLLFFICISLLCRYPQWRPRVYSIICRDSAPVKEVEGEGIVTKPLTPASIPAFSPNPGFNPTLGFSTTPRFSHPVSSTPISPVFGPSNWHNFVPPVREVVPTQGADPLLYGSLNPVPIPAPVRKWEDVVAAQPQRLDTADPAMLYAVVDGVPPTRWKEFMRLLGLSEHEIERLELQNGRCLREAHYSMLEAWRRRTPRHEATLDVVGRVLCDMNLRGCLENIRETLESPAHSSTTHLPR |
| Enzyme Length | 461 |
| Uniprot Accession Number | P22934 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (12); Domain (1); Glycosylation (3); Natural variant (2); Region (1); Repeat (4); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Apoptosis;Cell membrane;Disulfide bond;Glycoprotein;Golgi apparatus;Membrane;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..29; /evidence=ECO:0000250|UniProtKB:P19438 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11240015; 11412877; 12752784; 12786973; 12824249; 14552870; 14970118; 15117889; 15164724; 15353169; 15509749; 15590916; 15647744; 16077938; 16083358; 16442237; 17074049; 17109621; 17623297; 18552980; 19541932; 20501675; 20649583; 20651834; 20695884; 20700128; 20717874; 20828607; 20967881; 21224756; 21248590; 21252492; 21296062; 21359923; 21362018; 21404274; 21481476; 21690068; 21712071; 21741934; 21868309; 22372265; 22522145; 22531889; 22652595; 23028454; 23052485; 23333565; 23423194; 23874752; 24257399; |
| Motif | |
| Gene Encoded By | |
| Mass | 50,969 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |