| IED ID | IndEnz0002011109 |
| Enzyme Type ID | protease011109 |
| Protein Name |
Snake venom serine proteinase SVSP Kallidin-releasing enzyme EC 3.4.21.- Fragment |
| Gene Name | |
| Organism | Bitis arietans (African puff adder) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Viperinae (vipers) Bitis Bitis arietans (African puff adder) |
| Enzyme Sequence | VIGGDECDINEHRFLVFLTXASGLACGGTLIN |
| Enzyme Length | 32 |
| Uniprot Accession Number | Q9PRY9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Cleaves a kininogen analog with the release of kallidin (lysyl-bradykinin). Completely cleaves fibrinogen Aalpha chain, partially cleaves Bbeta chain and has no activity on gamma chain. {ECO:0000269|PubMed:8274016}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Non-terminal residue (1); Sequence uncertainty (3) |
| Keywords | Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Protease;Secreted;Serine protease;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8274016}. |
| Modified Residue | |
| Post Translational Modification | PTM: Contains 6 disulfide bonds. {ECO:0000250}.; PTM: Glycosylated. {ECO:0000269|PubMed:8274016}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 3,347 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.3 mM for tosyl-L-arginine methyl ester {ECO:0000269|PubMed:8274016}; |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |