| IED ID | IndEnz0002011139 |
| Enzyme Type ID | protease011139 |
| Protein Name |
ATP-dependent zinc metalloprotease YME1 homolog EC 3.4.24.- |
| Gene Name | ymel-1 M03C11.5 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MQSAINLNIGGLLQNTGLLRNSRNGINRKPLDIEATAASLSRVYHQVWRQFSSDTSSPVTINQMNNILRDSTLSRRIARKSEISLNYDDAVVRIIPASSSFYIQRRGFRTRKQTFGVGNAGKPTQDEVKSPLTYFSELLAGKKQKTSEGGVEKWNQYESDLKKLPENQQRTYTDGFVKGLLSNGVSGAGKDGKKSNTLTRFYIFLVFCIFFGYLTGRIRVRVGDRQIGSLFFSNPQEVNPEDVQVTFDDVRGMDEAKLEVEEIVDYLKDPEKYSRLGGRLPKGVLLVGPPGTGKTLLARAIAGEAQVPFFHTAGSEFDEVLVGQGARRVRDLFDKAKARAPCIIFIDEIDSVGSKRVSNSIHPYANQTINQLLSEMDGFTRNEGIIVIAATNRVDDLDKALLRPGRFDVRVTVPKPDLAGRVDIFNFYLSKIVHSGGIDPKVLAKGSTGFTGADIENMVNQAALKAATDNAVEVTMAYLDEARDRVLMGPARTGGRIPDEEANRNTAYHEAGHTLVSLYTKDATPLHKVTIIPRGQSLGHTAMLPEKDSYQLTKAQMLATLDVMMGGRVAEELIFGDDKVTTGAADDLSKATQLAVQMVKVFGMSDKVGLRDFTAQDNESALVKVSDLAPQTAELIDAEINRVLQESYKRAKVILETKKKEHQLLAEALLEYETLSADEVKRVISGQKIKRPTPAAVKKSNETKRNQPSLVLHLFEEEGRGKQ |
| Enzyme Length | 723 |
| Uniprot Accession Number | P54813 |
| Absorption | |
| Active Site | ACT_SITE 510; /evidence=ECO:0000250|UniProtKB:P0AAI3 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q96TA2}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 288..295; /note=ATP; /evidence=ECO:0000255 |
| Features | Active site (1); Chain (1); Metal binding (3); Nucleotide binding (1); Transmembrane (1) |
| Keywords | ATP-binding;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Nucleotide-binding;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96TA2}. Mitochondrion {ECO:0000250|UniProtKB:Q96TA2}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 21085631; 21177967; 21367940; 22286215; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 79,831 |
| Kinetics | |
| Metal Binding | METAL 509; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P0AAI3; METAL 513; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P0AAI3; METAL 587; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P0AAI3 |
| Rhea ID | |
| Cross Reference Brenda |