| IED ID |
IndEnz0002011144 |
| Enzyme Type ID |
protease011144 |
| Protein Name |
Apoptosis inhibitor UL38
|
| Gene Name |
UL38 |
| Organism |
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) |
| Taxonomic Lineage |
Viruses
Duplodnaviria
Heunggongvirae
Peploviricota
Herviviricetes
Herpesvirales
Herpesviridae
Betaherpesvirinae
Cytomegalovirus
Human cytomegalovirus (HHV-5) (Human herpesvirus 5)
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
|
| Enzyme Sequence |
MTTTTHSTAAIMSLLDEAEWRQTQMDVGGLIQASALGKVALRYAVRKLMKRGARLRHDSGLYVCICDPSYEFLQMNLSKISWLERHCPPLDQELIMFGVIEAWEEASVRPTRQLVLFMTPKWDVFAYDSGILFFLAPSMAQFWHGAIVLEYWNALFPVEVRSHVRQHAHTMDDLVMVFHQLDYEKQVLEARRDKNTEGPRTFAKSVNSYVRAILESERRIREGKIPMTFVDRDSLRANSLAHIQATGAQPSHAPAQRVLSAPPSLPSPVSEEDPAAAATPPSSAATTPPSSVVPASVESELSSSPPLPPVVVKDVMYTAGEGDVVQMVVVV |
| Enzyme Length |
331 |
| Uniprot Accession Number |
F5HG98 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
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| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2 (By similarity). Induces host mTORC1 activation by antagonizing the ability of host TSC1/2 to negatively regulate mTORC1. Thus, inhibits a growth regulatory pathway to facilitate viral replication. Prevents premature cell host cell death by blocking host ubiquitin-specific protease 24/USP24-mediated autophagic ferritin degradation in lysosomes thus maintaining lysosome integrity and cellular viability (PubMed:29695420). {ECO:0000250|UniProtKB:Q9WT45, ECO:0000269|PubMed:17202209, ECO:0000269|PubMed:18407068, ECO:0000269|PubMed:21715486, ECO:0000269|PubMed:29695420}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Region (1) |
| Keywords |
Host cytoplasm;Host nucleus;Host-virus interaction;Modulation of host cell apoptosis by virus;Reference proteome |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:17202209}. Host nucleus {ECO:0000269|PubMed:17202209}. Note=localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
36,753 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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