| IED ID | IndEnz0002011195 |
| Enzyme Type ID | protease011195 |
| Protein Name |
Zinc metalloproteinase-disintegrin-like kaouthiagin-like K-like EC 3.4.24.- Snake venom metalloproteinase SVMP |
| Gene Name | |
| Organism | Naja atra (Chinese cobra) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Elapidae Elapinae Naja Naja atra (Chinese cobra) |
| Enzyme Sequence | MIQALLVIICLAVFPHQGSSIILESGNVNDYEVVYPQKVPALLKGGVQNPQPETKYEDTMRYEFQVNGEPVVLHLERNKGLFSEDYTETHYAPDGREITTSPPVQDHCYYHGYIQNEADSSAVISACDGLKGHFEHQGETYFIEPLKISNSEAHAIYKDENVENEDETPEICGVTETTWESDESIEKTSQFTNTPEQDRYLQDKKYIEFYVIVDNRMYRYYNNDKPAIKIRVYEMINAVNTKFRPLKIHIALIGLEIWSNKDKFEVKPAASVTLKSFGEWRETVLLPRKRNDNAQLLTGIDFNGNTVGRAYIGSLCKTNESVAIVQDYNRRISLVASTITHELGHNLGIHHDKASCICIPGPCIMLKKRTAPAFQFSSCSIREYREYLLRDRPQCILNKPLSTDIVSPPICGNYFVEVGEECDCGSPQACQSACCNAATCQFKGAETECRVAKDDCDLPELCTGQSAECPTDSLQRNGHPCQNNQSYCYNGTCPTLTNQCITLLGPHFTVSPKGCFDLNMRGDDGSFCRMEDGTKIPCAAKDVKCGRLYCTEKNTMSCLIPPNPDGIMAEPGTKCGDGMVCSKGQCVDVQTAY |
| Enzyme Length | 593 |
| Uniprot Accession Number | D3TTC1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom zinc metalloproteinase that cleaves the membrane-bound precursor of TNF-alpha (TNF) into its mature soluble form showing the same digestion pattern than ADAM17. {ECO:0000269|PubMed:19932752}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (14); Chain (1); Disulfide bond (15); Domain (2); Glycosylation (2); Helix (11); Metal binding (18); Motif (1); Propeptide (1); Sequence conflict (2); Signal peptide (1); Turn (6) |
| Keywords | 3D-structure;Calcium;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Toxin;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 3K7N; |
| Mapped Pubmed ID | - |
| Motif | MOTIF 455..457; /note=D/ECD-tripeptide |
| Gene Encoded By | |
| Mass | 66,292 |
| Kinetics | |
| Metal Binding | METAL 208; /note=Calcium 1; METAL 292; /note=Calcium 1; METAL 341; /note=Zinc; catalytic; METAL 345; /note=Zinc; catalytic; METAL 351; /note=Zinc; catalytic; METAL 395; /note=Calcium 1; via carbonyl oxygen; METAL 398; /note=Calcium 1; METAL 410; /note=Calcium 2; via carbonyl oxygen; METAL 413; /note=Calcium 2; METAL 415; /note=Calcium 2; via carbonyl oxygen; METAL 417; /note=Calcium 2; METAL 420; /note=Calcium 2; METAL 423; /note=Calcium 2; METAL 457; /note=Calcium 3; METAL 458; /note=Calcium 3; via carbonyl oxygen; METAL 460; /note=Calcium 3; METAL 472; /note=Calcium 3; METAL 473; /note=Calcium 3; via carbonyl oxygen |
| Rhea ID | |
| Cross Reference Brenda |