| IED ID | IndEnz0002011235 |
| Enzyme Type ID | protease011235 |
| Protein Name |
Protein-glutamine gamma-glutamyltransferase EC 2.3.2.13 MTG Transglutaminase TGase |
| Gene Name | |
| Organism | Streptomyces mobaraensis (Streptoverticillium mobaraense) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Streptomycetales Streptomycetaceae Streptomyces Streptomyces mobaraensis (Streptoverticillium mobaraense) |
| Enzyme Sequence | MRIRRRALVFATMSAVLCTAGFMPSAGEAAADNGAGEETKSYAETYRLTADDVANINALNESAPAASSAGPSFRAPDSDDRVTPPAEPLDRMPDPYRPSYGRAETVVNNYIRKWQQVYSHRDGRKQQMTEEQREWLSYGCVGVTWVNSGQYPTNRLAFASFDEDRFKNELKNGRPRSGETRAEFEGRVAKESFDEEKGFQRAREVASVMNRALENAHDESAYLDNLKKELANGNDALRNEDARSPFYSALRNTPSFKERNGGNHDPSRMKAVIYSKHFWSGQDRSSSADKRKYGDPDAFRPAPGTGLVDMSRDRNIPRSPTSPGEGFVNFDYGWFGAQTEADADKTVWTHGNHYHAPNGSLGAMHVYESKFRNWSEGYSDFDRGAYVITFIPKSWNTAPDKVKQGWP |
| Enzyme Length | 407 |
| Uniprot Accession Number | P81453 |
| Absorption | |
| Active Site | ACT_SITE 140; ACT_SITE 331; ACT_SITE 350 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011, ChEBI:CHEBI:138370; EC=2.3.2.13; |
| DNA Binding | |
| EC Number | 2.3.2.13 |
| Enzyme Function | FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (11); Chain (1); Compositional bias (1); Helix (16); Propeptide (1); Region (2); Signal peptide (1); Turn (5) |
| Keywords | 3D-structure;Acyltransferase;Direct protein sequencing;Signal;Transferase;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..31; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1IU4; 3IU0; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,684 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:54816 |
| Cross Reference Brenda | 2.3.2.13; |