| IED ID | IndEnz0002011319 |
| Enzyme Type ID | protease011319 |
| Protein Name |
Serine protease 1 EC 3.4.21.4 Anionic trypsin I Anionic trypsin-1 Beta-trypsin Cationic trypsinogen Pretrypsinogen I Trypsin I Trypsin-1 |
| Gene Name | Prss1 Trp1 Try1 Tryp1 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MSALLILALVGAAVAFPLEDDDKIVGGYTCPEHSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGDEQFINAAKIIKHPNYSSWTLNNDIMLIKLSSPVKLNARVAPVALPSACAPAGTQCLISGWGNTLSNGVNNPDLLQCVDAPVLSQADCEAAYPGEITSSMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCALPDNPGVYTKVCNFVGWIQDTIAAN |
| Enzyme Length | 246 |
| Uniprot Accession Number | P00762 |
| Absorption | |
| Active Site | ACT_SITE 63; /note=Charge relay system; ACT_SITE 107; /note=Charge relay system; ACT_SITE 200; /note=Charge relay system |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; |
| DNA Binding | |
| EC Number | 3.4.21.4 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (6); Domain (1); Metal binding (4); Propeptide (1); Signal peptide (1); Site (1) |
| Keywords | Calcium;Digestion;Direct protein sequencing;Disulfide bond;Hydrolase;Metal-binding;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11062314; 2363685; 2422952; 2460970; 2726780; 3833185; 8625754; 9688663; |
| Motif | |
| Gene Encoded By | |
| Mass | 25,959 |
| Kinetics | |
| Metal Binding | METAL 75; /note=Calcium; METAL 77; /note=Calcium; via carbonyl oxygen; METAL 80; /note=Calcium; via carbonyl oxygen; METAL 85; /note=Calcium |
| Rhea ID | |
| Cross Reference Brenda |