| IED ID | IndEnz0002011320 |
| Enzyme Type ID | protease011320 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 40 EC 3.4.19.12 Deubiquitinating enzyme 40 Ubiquitin thioesterase 40 Ubiquitin-specific-processing protease 40 |
| Gene Name | Usp40 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MFGNLFEEDYSSVSSSQYGRGKKLKTKGLEPPAPREFTNLSGIRNQGGTCYLSSLLQTLHFTPEFREALFSLGPEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTIDLTDSFGWTNDEEMRQHDVQELNRILFSALETSLVGTSGHDLIHRLYHGTIVNQIVCKECKNISERQEDFLDLTVAVKNVSGLEDELCNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKPFCEQSELDDMEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQCQEEISDTNVNVKAPQSEEEANDPLVVLKTILLQEEANQIPVDQLGQKLLKKTGISWNKKYRKQHGPLRKFLQLHPQIFLLSTDESTVSLLRNHLTQAPSDLQSCEQILHTLASESPGLNDDTSCPHWFDINDSKVHPIREKDITQQFQGKESAYMLFYRKATLQRPPEARANPRYRVPCHLLKEMDAANILLQMRRAECDSANSTFELHLHLGPHYRFFNGALHPAVSETESVWDLTFDKRKTLGDLRQSIFQLLECWEGDMVLSVAKRVPAGLHVYHTLDGDDLTLCEAEVADGEDIFVWNGVEVGGVQIQTGFDCEPLLLNILHLELSGEGSKCEQLVESPHVFPANAEVGAVFTALGTPAGAILMNSVESADGECWTAVPKEDMKKTFREQGLRNGSLILVQDSDSDNNSLLPKQGRWTNSMNELNWLQVKNFCQSESEEKQVQIAVTMHTVVFDIRIKAIKELKLMKELAENSCLRPIDRNGKLLCPVPDSSTLEEAEVKMGSSVGLCLGKAPTSSQLFLFFALGTDIHPGAEMDIIVEETLSVRDCLKIMLEKSGQQGEIWHLRKMDWCYEAGEPLCEEDATLKELMIRSGDTLLLTEGKLPPPGHLKMPIWWYQPARLSGHCESRDHLNCAFSQDSTWRAAPTQGAPGPEPAEVSLLYLGDMEISEEATLVELKSQALALPSVSKLAVQSTALLRVWTVESKRPSRLLRTNWRQLKEYRLGRRAELCLELLQKEEDLGPRDVLLRTQLRIPGERAYSLATDLIWDTTRGWTAGSLRQRVADFYSLPVEKIEIAKYFPEKFEWLPISSWNQQVAKRKKKKNQDTLQGGPYYLKDGDTIGIKNLLFDDNDDFSTIRDDIGKENQKRLALEKKKSREVHRAQSSDLFSNAGVPARFRGPEASLSIHVASFR |
| Enzyme Length | 1235 |
| Uniprot Accession Number | Q8BWR4 |
| Absorption | |
| Active Site | ACT_SITE 50; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (4); Chain (1); Domain (1); Sequence conflict (4) |
| Keywords | Alternative splicing;Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 14581517; 14610273; 21267068; |
| Motif | |
| Gene Encoded By | |
| Mass | 139,952 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |