| IED ID | IndEnz0002011350 |
| Enzyme Type ID | protease011350 |
| Protein Name |
von Willebrand factor vWF Cleaved into: von Willebrand antigen 2 von Willebrand antigen II |
| Gene Name | Vwf |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MNPFRYEICLLVLALTWPGTLCTEKPRDRPSTARCSLFGDDFINTFDETMYSFAGGCSYLLAGDCQKRSFSILGNFQDGKRMSLSVYLGEFFDIHLFANGTVMQGDQSISMPYASQGLYLELEAGYYKLSSETFGFAARIDGNGNFQVLMSDRHFNKTCGLCGDFNIFAEDDFRTQEGTLTSDPYDFANSWALSSEEQRCKRASPPSRNCESSSGDMHQAMWEQCQLLKTASVFARCHPLVDPESFVALCEKILCTCATGPECACPVLLEYARTCAQEGMVLYGWTDHSACRPACPAGMEYKECVSPCPRTCQSLSINEVCQQQCVDGCSCPEGELLDEDRCVQSSDCPCVHAGKRYPPGTSLSQDCNTCICRNSLWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCEDHTFSIVIETMQCADDPDAVCTRSVSVRLSALHNSLVKLKHGGAVGIDGQDVQLPFLQGDLRIQHTVMASVRLSYAEDLQMDWDGRGRLLVKLSPVYSGKTCGLCGNYNGNKGDDFLTPAGLVEPLVVDFGNAWKLQGDCSDLRRQHSDPCSLNPRLTRFAEEACALLTSSKFEACHHAVSPLPYLQNCRYDVCSCSDSRDCLCNAVANYAAECARKGVHIGWREPGFCALGCPQGQVYLQCGNSCNLTCRSLSLPDEECSEVCLEGCYCPPGLYQDERGDCVPKAQCPCYYDGELFQPADIFSDHHTMCYCEDGFMHCTTSGTLGSLLPDTVLSSPLSHRSKRSLSCRPPMVKLVCPADNPRAQGLECAKTCQNYDLERMSLGCVSGCLCPPGMVRHENKCVALERCPCFHQGAEYAPGDTVKIGCNTCVCRERKWNCTNHVCDATRSAIGMAHYLTFDGLKYLFPGECQYVLVYDYCGSNPGTFQILVGNEGCSYPSVKCRKRVTILVDGGELELFDGEVNVKRPLRDESHFEVVESGRYVILLLGQALSVVWDHHLSISVVLKHTYQEQVCGLCGNFDGIQNNDSTTSSLQVEEDPVNFGNSWKVSSQCADTRKLSLDVSPATCHNNIMKQTMVDSACRILTSDVFQGCNRLVDPEPYLDICIYDTCSCESIGDCACFCDTIAAYAHVCAQHGQVVAWRTPTLCPQSCEEKNVRENGYECEWRYNSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGRILDELLQTCVDPQDCPVCEVAGRRLAPGKKITLSPDDPAHCQNCHCDGVNLTCEACQEPGGLVAPPTDAPVSSTTPYVEDTPEPPLHNFYCSKLLDLVFLLDGSSMLSEAEFEVLKAFVVGMMERLHISQKRIRVAVVEYHDGSRAYLELKARKRPSELRRITSQIKYTGSQVASTSEVLKYTLFQIFGKIDRPEASHITLLLTASQEPPRMARNLVRYVQGLKKKKVIVIPVGIGPHASLKQIRLIEKQAPENKAFLLSGVDELEQRRDEIVSYLCDLAPEAPAPTQPPQVAHVTVSPGIAGISSPGPKRKSMVLDVVFVLEGSDEVGEANFNKSKEFVEEVIQRMDVSPDATRISVLQYSYTVTMEYAFNGAQSKEEVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDRVEAPNLVYMVTGNPASDEIKRLPGDIQVVPIGVGPHANMQELERISRPIAPIFIRDFETLPREAPDLVLQTCCSKEGLQLPTLPPLPDCSQPLDVVLLLDGSSSLPESSFDKMKSFAKAFISKANIGPHLTQVSVIQYGSINTIDVPWNVVQEKAHLQSLVDLMQQEGGPSQIGDALAFAVRYVTSQIHGARPGASKAVVIIIMDTSLDPVDTAADAARSNRVAVFPVGVGDRYDEAQLRILAGPGASSNVVKLQQVEDLSTMATLGNSFFHKLCSGFSGVCVDEDGNEKRPGDVWTLPDQCHTVTCLANGQTLLQSHRVNCDHGPRPSCANSQSPVRVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVIFQNKEQDLEVLLHNGACSPGAKQACMKSIEIKHAGVSAELHSNMEMAVDGRLVLAPYVGENMEVSIYGAIMYEVRFTHLGHILTYTPQNNEFQLQLSPKTFASKMHGLCGICDENGANDFTLRDGTVTTDWKRLVQEWTVQQPGYTCQAVPEEQCPVSDSSHCQVLLSASFAECHKVIAPATFHTICQQDSCHQERVCEVIASYAHLCRTSGVCVDWRTTDFCAMSCPPSLVYNHCERGCPRHCDGNTSFCGDHPSEGCFCPQHQVFLEGSCVPEEACTQCVGEDGVRHQFLETWVPDHQPCQICMCLSGRKINCTAQPCPTARAPTCGPCEVARLKQSTNLCCPEYECVCDLFNCNLPPVPPCEGGLQPTLTNPGECRPTFTCDCRKEECKRVSPPSCPPHRTPTLRKTQCCDEYECACSCVNSTLSCPLGYLASATTNDCGCTTTTCLPDKVCVHRGTVYPVGQFWEEGCDTCTCTDMEDTVVGLRVVQCSQRPCEDSCQPGFSYVLHEGECCGRCLPSACKVVAGSLRGDSHSSWKSVGSRWAVPENPCLVNECVRVEDAVFVQQRNISCPQLAVPTCPTGFQLNCETSECCPSCHCEPVEACLLNGTIIGPGKSVMVDLCTTCRCIVQTDAISRFKLECRKTTCEACPMGYREEKSQGECCGRCLPTACTIQLRGGRIMTLKQDETFQDGCDSHLCRVNERGEYIWEKRVTGCPPFDEHKCLAEGGKIVKIPGTCCDTCEEPDCKDITAKVQYIKVGDCKSQEEVDIHYCQGKCASKAVYSIDIEDVQEQCSCCLPSRTEPMRVPLHCTNGSVVYHEVINAMQCRCSPRNCSK |
| Enzyme Length | 2813 |
| Uniprot Accession Number | Q8CIZ8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. {ECO:0000250|UniProtKB:P04275, ECO:0000269|PubMed:10930441}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Beta strand (6); Chain (2); Disulfide bond (34); Domain (15); Erroneous initiation (1); Glycosylation (24); Helix (7); Motif (1); Mutagenesis (1); Region (4); Sequence conflict (10); Signal peptide (1); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Blood coagulation;Cell adhesion;Cleavage on pair of basic residues;Disulfide bond;Extracellular matrix;Glycoprotein;Hemostasis;Reference proteome;Repeat;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Localized to storage granules. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds. {ECO:0000250|UniProtKB:P04275}.; PTM: N- and O-glycosylated. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000250|UniProtKB:P04275 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1U0O; |
| Mapped Pubmed ID | 10359181; 10441735; 10625534; 10688827; 10706142; 10926765; 10976050; 10981960; 11015584; 11071623; 11154109; 11154224; 11159184; 11212329; 11389024; 11493531; 11520791; 11691837; 11807041; 11891199; 12160745; 12217325; 12393668; 12466851; 12526796; 12556486; 12606288; 1317267; 1384789; 14604963; 14610273; 14981081; 15239958; 15322537; 15327970; 15572153; 15591414; 15616565; 15731176; 15875024; 15956287; 15967814; 1630810; 16505993; 16638935; 16788103; 16823491; 16824188; 16873672; 16895970; 16956626; 16980969; 17003372; 17013884; 17119108; 17148587; 17155961; 17376515; 17380206; 17438136; 17656671; 17699753; 17996853; 18048367; 18058911; 18059000; 18083848; 18084279; 18187670; 18245384; 18256319; 18263586; 18281502; 18395835; 18469803; 18485763; 18487513; 18550847; 18556568; 18559674; 18627106; 18688020; 18695007; 18752568; 18802014; 18992737; 19036705; 19088380; 19182208; 19332769; 1936575; 19377048; 19619540; 19644667; 19687510; 19705428; 19737616; 19769963; 19789385; 19808696; 19864314; 19910638; 19965676; 20164094; 20194895; 20200350; 20360471; 20363914; 20371742; 20457761; 20530543; 20551517; 20558824; 20606161; 20616311; 20624989; 20684947; 20695979; 20704649; 20713964; 20716766; 20959603; 21037087; 21048155; 21148427; 21172336; 21220740; 21266777; 21267068; 21300875; 21346256; 21570975; 21693521; 21708977; 22001909; 22012621; 22134168; 22159717; 22267483; 22372972; 22374700; 22437503; 22539596; 22616016; 22622036; 22642380; 22712744; 22855607; 22915646; 22962592; 22972987; 22983446; 23139760; 23178125; 23335368; 23335371; 23343833; 23426945; 23529929; 23580145; 23720451; 23737952; 23797810; 23812299; 23823180; 23825365; 23840065; 23863621; 23945153; 24006456; 24081657; 24200682; 24261607; 24270421; 24357063; 24504734; 24553180; 24553181; 24642750; 24700724; 24713928; 24733925; 24755984; 24805242; 24850761; 24951431; 24982209; 25051961; 25091710; 25147341; 25180602; 25293780; 25343959; 25401279; 25650553; 25681586; 25690668; 25728415; 25931511; 25955153; 25977583; 26047609; 26156014; 26209660; 26329599; 26494840; 26511133; 26517044; 26527618; 26565707; 26743845; 26744078; 26878215; 26952749; 26953188; 27125875; 27207787; 27212476; 27444201; 27507004; 27554083; 27602496; 27782211; 27889498; 27943541; 28071719; 28216153; 28428179; 28487393; 28495930; 28527913; 28572286; 28581694; 28642239; 28643773; 28684544; 28868583; 28924218; 29097365; 29106382; 29114040; 29251627; 29282218; 29348121; 29392565; 29456137; 29729651; 29941674; 30026593; 30033122; 30124466; 30287479; 30565388; 30566624; 30573509; 30665023; 30898865; 30936179; 30936549; 30975637; 31099973; 31112136; 31315435; 31351040; 31501155; 31594977; 31594992; 31606553; 31758944; 31902309; 32059772; 32135568; 32870970; 32967458; 32998468; 33057196; 33372189; 33507292; 33939120; 34478462; 34619301; 7490564; 7502236; 7526952; 7681362; 7683699; 7854452; 7896277; 7987303; 8118024; 8179996; 8201022; 8318738; 8562500; 8678996; 8782436; 8817457; 8918453; 8950511; 8986815; 9384381; 9686317; 9689083; 9689113; 9806594; |
| Motif | MOTIF 2507..2509; /note=Cell attachment site; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 309,269 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |