| IED ID | IndEnz0002011364 |
| Enzyme Type ID | protease011364 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase usp-48 EC 3.4.19.12 Ubiquitin-specific protease 48 |
| Gene Name | usp-48 F30A10.10 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MTKETDKKPKERPNQRKVAFRNEAINALVNTDEDQVTFSKAMEVAKLDCQKCLLHDMHSSKSSNCRDNPFCIHRLGLEKFEKLITQEQETKEEAKKDQKRRDLNDQPAGLINGGNFCYVNSFLQVWFNVPEFRQLIYDFRPSENFVPPEAPRMNVQATMLALQDIFYTLQTTPFNETDKTSNLGKLLRLNSEQQDSQEFGLKFFNALERCLPDHPNGKETLKRLKDLFTGETCTRIVCKCGQRSEREETAISLTLNIEGYCTLLDALDAYFGEEHLDDFKCSKCNKTGDVSKQSDYVKLPPVIVIQLNRYKYTSKGRQKLKTPMAYPREIPAKAFQRTNNSIPPPAEMYDLFAVTIHEGNNAECGHYYDLIKSPLNQKWYRYNDEAIEAIPKPPGTEKPTTAKTEKSRKKDKEKYPTDQKACYGLLYRRRDAFKPLPHPKLPPEELIIDSKTEIEELFEGLTKKKIEKSEKRLYDLERRINKVKISYGKLETHSDKYKEANEVVFLPTTLLQDVLAQEYEVAKGEKKKKKKEASENEEKKKNEEDEALSAAIAASEADQRDKASSEPSTSAAATEAGDDEELRAESETPNPENAESTQVAIMETDEIMDTTPTKDIDILAKAMEDNALPTVEVPQPELKKRTRQQNGEVKYVYSQRTPRKSHNGTNGTNSSPQKQPVSSRVAALLSSHEIPTCGHGKMSIDPILYGDVKAVSRAPAIALLREYDFRVKIVYDNGENVFPENEKERDVFIFTAEDICMECVREMREEGNFNNQLEDDEKLVRRILKEEKQRCSVKCPSERPDGYLYVAKFALSNFKKSAMSARENRLAQSHNKQGTLHFDSHPMFQQKSNSGYLTLSLKRTRGKPRKSLSEIPEKMQKLDEIGSKELPDEIIADEEEISENMGSDIPTKPVESINPDALVPFEKIEFNSELRCSHGGINFNQFRLSVSPEEWAHLKVYFDECYEVKCSDDVCDQCRQMEVDAQNGSENMRGLVREMRKRISDTLKTVESRAESKEDGADIKYGICSVFIDKLRKLTSRQSTSPPSICQECLLCPHQQPFKGFLNEDNHKDSHVVGLTEEEWNTFLTEIRKLEEAGDDQSIAVDPCPIPIENGQIVDMCEKCFEQHIKFTEEQKYMFENENIYVKLVNLNVEEDIAKANGKARRGRAKNLYAIKMSSTNKLMELKVQLYDKTHQLPNDQLLYRTAGGEQFDVSNNQKTLFDLRLSPNNNDNPLILIAQQFSPSASQADETGDRAPERGFVDTALAH |
| Enzyme Length | 1264 |
| Uniprot Accession Number | G5ECC7 |
| Absorption | |
| Active Site | ACT_SITE 117; /note=Nucleophile; /evidence=ECO:0000255|PROSITE-ProRule:PRU01035; ACT_SITE 366; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU01035 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q86UV5}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression (PubMed:31088904). {ECO:0000250|UniProtKB:Q86UV5, ECO:0000269|PubMed:31088904}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Chain (1); Coiled coil (1); Compositional bias (4); Domain (1); Mutagenesis (3); Region (3) |
| Keywords | Alternative splicing;Chromosome;Coiled coil;Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31088904}. Chromosome {ECO:0000269|PubMed:31088904}. Note=In pachytene germline cells and oocytes, localizes to chromosomes. {ECO:0000269|PubMed:31088904}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12242227; 12445391; 14551910; 16710447; 18006689; 19165329; 20308279; 20439774; 21177967; 21343362; 21909284; 22286215; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 144,457 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |