| IED ID | IndEnz0002011390 |
| Enzyme Type ID | protease011390 |
| Protein Name |
Ubiquitin-like protease 4 EC 3.4.22.- |
| Gene Name | ulp-4 C41C4.6 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MEVSTSYCTPAVNFKYGSFQDSDVSMREDDLFRMGSYNSQGYYADGTHLDGSIGEEDETSSGSNDQHMDFEEDDFDMESSMTEDLVDEDEEEEDEEDNDEWTNQKRTDNQNSVAYYAAMEMLRIRFPFQSIAIRISDFCCLQEKDLLNDTMIDFYLNHIVEHVLPDSNGSNVTVLPSIFWHNLSLRQHAFDSEDEKMMSDEQKMDLKFGDLHDFVADFDLQDFDYIVVPVNEWEHWSLAVICHPFTAQARTVIFDSQLTADLNNLQNMATLIESFMKYSYEKRTGNAMPFPLPCILPQRMPQQTNNFDCGIFIAEFARRFLLSPPKDLDNFDFAREYPDFSTATKRTEMQRVVLSLSTNRARWRPLVELLNGYSTAAPHRAL |
| Enzyme Length | 382 |
| Uniprot Accession Number | Q09275 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression (PubMed:25475837) (Probable). Required for respiration and the maintenance of normal mitochondrial homeostasis (PubMed:25187565). In response to mitochondrial stress, required for the removal of smo-1 conjugates from the transcription factor dve-1, which promotes the translocation of dve-1 from the cytosol to the nucleus to initiate the mitochondrial unfolded protein response (PubMed:30642431). Furthermore, removes the smo-1 conjugates from the transcription factor atfs-1 to promote its stability and activate the mitochondrial unfolded protein response (PubMed:30642431). Also plays a role in promoting mitochondrial unfolded protein response-mediated innate immunity following infection with P.aeruginosa (PubMed:30642431). {ECO:0000269|PubMed:25187565, ECO:0000269|PubMed:25475837, ECO:0000269|PubMed:30642431, ECO:0000305|PubMed:30642431}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein modification; protein sumoylation. {ECO:0000269|PubMed:30642431}. |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Region (1) |
| Keywords | Cytoplasm;Cytoskeleton;Hydrolase;Mitochondrion;Nucleus;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | INDUCTION: Up-regulated in response to mitochondrial stress induced by antimycin A. {ECO:0000269|PubMed:30642431}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25475837}. Nucleus {ECO:0000269|PubMed:25187565}. Cytoplasm {ECO:0000269|PubMed:25187565}. Mitochondrion matrix {ECO:0000269|PubMed:25187565}. Note=Localizes around the metaphase plate and the pericentriolar region and in the surroundings of the central spindle (PubMed:25475837). Translocates from cytoplasm to mitochondrion at late developmental stages (PubMed:25187565). {ECO:0000269|PubMed:25187565, ECO:0000269|PubMed:25475837}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12097347; 12529635; 14551910; 15687288; 16049479; 16824923; 17164286; 19343510; 21085631; 21177967; 21367940; 22286215; 22347378; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,290 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |