| IED ID | IndEnz0002011435 |
| Enzyme Type ID | protease011435 |
| Protein Name |
Coagulation factor X-activating enzyme heavy chain EC 3.4.24.58 Coagulation factor X-activating enzyme chain alpha RVV-X heavy chain Snake venom metalloproteinase SVMP Fragment |
| Gene Name | |
| Organism | Daboia russelii (Russel's viper) (Vipera russelii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Viperinae (vipers) Daboia Daboia russelii (Russel's viper) (Vipera russelii) |
| Enzyme Sequence | VATSEQFNKTFIELVIVVD |
| Enzyme Length | 19 |
| Uniprot Accession Number | P86536 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of Arg-|-Xaa bonds. Has no action on insulin B chain.; EC=3.4.24.58; Evidence={ECO:0000250|UniProtKB:Q7LZ61}; |
| DNA Binding | |
| EC Number | 3.4.24.58 |
| Enzyme Function | FUNCTION: Catalytic subunit of coagulation factor X-activating enzyme, a zinc-protease enzyme that acts in hemostasis. Activates coagulation factor X (F10) by cleaving the Arg-Ile bond at position 234 and is also able to activate coagulation factor IX (F9) and protein C (PROC) by specific cleavage of Arg-Ile and Arg-Val bonds (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Non-terminal residue (1) |
| Keywords | Blood coagulation cascade activating toxin;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20203422}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q7LZ61}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,152 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |