| IED ID | IndEnz0002011451 |
| Enzyme Type ID | protease011451 |
| Protein Name |
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Growth and differentiation factor-associated serum protein 1 GASP-1 mGASP-1 |
| Gene Name | Wfikkn2 Gasp1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MCAPGYHRFWFHWGLLLLLLLEAPLRGLALPPIRYSHAGICPNDMNPNLWVDAQSTCKRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCFMDAEACSKGITLSVVTCRYHFTWPNTSPPPPETTVHPTTASPETLGLDMAAPALLNHPVHQSVTVGETVSFLCDVVGRPRPELTWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNVQPQDAGIYTCTARNVAGVLRADFPLSVVRGGQARATSESSLNGTAFPATECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHHNLNHFETYEACMLACMSGPLAICSLPALQGPCKAYVPRWAYNSQTGLCQSFVYGGCEGNGNNFESREACEESCPFPRGNQHCRACKPRQKLVTSFCRSDFVILGRVSELTEEQDSGRALVTVDEVLKDEKMGLKFLGREPLEVTLLHVDWTCPCPNVTVGETPLIIMGEVDGGMAMLRPDSFVGASSTRRVRKLREVMYKKTCDVLKDFLGLQ |
| Enzyme Length | 571 |
| Uniprot Accession Number | Q7TQN3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). Inhibits the biological activity of mature myostatin, but not activin. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (4); Chain (1); Disulfide bond (17); Domain (6); Glycosylation (2); Helix (1); Sequence conflict (1); Signal peptide (1); Site (1) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Immunoglobulin domain;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12595574}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..29; /evidence=ECO:0000269|PubMed:12595574 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 6MAA; |
| Mapped Pubmed ID | 11217851; 12364608; 12466851; 18596030; 19906978; 20164830; 21267068; 21677750; 22937083; 23046573; 24019467; 30814254; 31960486; |
| Motif | |
| Gene Encoded By | |
| Mass | 63,333 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |