| IED ID | IndEnz0002011472 |
| Enzyme Type ID | protease011472 |
| Protein Name |
Snake venom metalloproteinase acutolysin-A SVMP EC 3.4.24.- Hemorrhagin I HI |
| Gene Name | |
| Organism | Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Deinagkistrodon Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) |
| Enzyme Sequence | MIQVLLVTICLAAFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAVQQKYEDAMQYEFKVNGEPVVLHLEKNKGLFSKDYSEIHYSPDGRRITTHPLVEDHCYYRGHIRNDADSTASISACNGLKGHFKLQGEMYLIEPMKMSYSEAHAVYKYGNVEKEDEAPKMCGVTQNWESYEPIKKASQLIVSTEFQRYMEIVIVVDHSMVKKYNGDSDKIKAWVYEMINTITESYSYLYIDIILSGLEIWSEKDLINVETSAENTLKSFGEWRAKDLIHRISHDNAQLLTATDFDGPTIGLAYVASMCDPKRSVGVVQDHSSVNRLVAITLAHEMAHNLGVRHDEGSCSCGSGYTCIMSPVINSEVIKYFSDCSYIQCREYISKENPPCILNKPLRTDTVSTPVSGNELLEAGKDYD |
| Enzyme Length | 413 |
| Uniprot Accession Number | Q9PW35 |
| Absorption | |
| Active Site | ACT_SITE 330; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: This protein is a zinc metalloprotease from snake venom that possesses hemorrhagic activity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (6); Chain (1); Disulfide bond (3); Domain (1); Helix (7); Metal binding (7); Propeptide (2); Signal peptide (1); Turn (3) |
| Keywords | 3D-structure;Calcium;Direct protein sequencing;Disulfide bond;Hemorrhagic toxin;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Toxin;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1BSW; 1BUD; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 46,565 |
| Kinetics | |
| Metal Binding | METAL 196; /note=Calcium; METAL 280; /note=Calcium; METAL 329; /note=Zinc; catalytic; METAL 333; /note=Zinc; catalytic; METAL 339; /note=Zinc; catalytic; METAL 385; /note=Calcium; via carbonyl oxygen; METAL 388; /note=Calcium |
| Rhea ID | |
| Cross Reference Brenda |