| IED ID | IndEnz0002011545 |
| Enzyme Type ID | protease011545 |
| Protein Name |
Probable intramembrane protease C25B8.17 EC 3.4.23.- |
| Gene Name | SPAC25B8.17 |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MEGVILASSALFTVYIGAKWSAQEEEPEEKQLINKRLAVLFPIFGGVTLVLMYLALRYLSKEYIQLILQGYASLASIICFVRSFNPKTTFGKITATMSSIAIALFYFKTKHWMASNILAWALAANSISIMRIDSYNTGALLLGALFFYDIYFVFGTEVMVTVATGIDIPAKYVLPQFKNPTRLSMLGLGDIVMPGLMLALMYRFDLHYYINSTSQPKKHSTYFRNTFIAYGLGLGVTNFALYYFKAAQPALLYLSPACIVAPLLTAWYRDELKTLFSFRSETEDETDEQDKCKST |
| Enzyme Length | 295 |
| Uniprot Accession Number | Q9UTA3 |
| Absorption | |
| Active Site | ACT_SITE 149; /evidence=ECO:0000250; ACT_SITE 190; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Motif (1); Topological domain (9); Transmembrane (9) |
| Keywords | Endoplasmic reticulum;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16491466; 20473289; 23173672; 23697806; |
| Motif | MOTIF 249..251; /note=PAL |
| Gene Encoded By | |
| Mass | 33,234 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |